Skip to main content

Table 2 Association analysis of genes polymorphisms with the response to antiviral treatment

From: Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C

Genotype/ Allele

SVR

NR

P value

OR(95%CI)

N = 91

N = 109

CYP2R1 rs10741657 [n(%)]

  

Chi2 = 5.38 p = 0.06

 A/A

7(7.7)

4(3.7)

  

 A/G

44(48.4)

40(36.7)

  

 G/G

40(44)

59.6))65

0.028

0.531(0.302-0.933)

A allele carriers/A allele non carriers

51/40

44/65

0.027

1.884(1.072-3.310)

VDR rs2228570 [n(%)]

  

Chi2 = 8.66 p = 0.013

 A/A

13(14.3)

4(3.7)

0.013

4.375(1.374-13.932)

 A/G

36(39.6)

39(35.8)

  

 G/G

42(46.2)

66(60.6)

  

A allele carriers/A allele non carriers

49/42

43/66

0.042

1.791(1.019-3.146)

VDR rs1544410 [n(%)]

  

n.s.

 C/C

30(33)

38(34.9)

  

 C/T

39(42.9)

47(43.1)

  

 T/T

22(24.9)

24(22)

  

T allele carriers/ T allele non carriers

61/30

71/38

  

OASL rs1169279 [n(%)]

  

Chi2 = 5.4 p = 0.06

 C/C

19(20.9)

39(55.8)

0.022

0.474(0.250-0.898)

 C/T

52(57.1)

49(45)

  

 T/T

20(22)

21(19.3)

  

T allele carriers/ T allele non carriers

72/19

70/39

0.013

2.26(1.182-4.318)

ADAR rs1127309 [n(%)]

  

n.s.

 C/C

30(33)

38(34.9)

  

 C/T

39(42.9)

47(43.1)

  

 T/T

22(24.2)

24(22)

  

T allele carriers/ T allele non carriers

61/30

71/109

  
  1. OR, odds ratio; 95%CI Confidence Interval; n.s., non-significant; SVR: sustained viral response; NR: non response; CYP2R1: cytochrome P-450 family 2, subfamily R; VDR: vitamin D receptor; OASL: oligoadenylate synthetases-like; ADAR: adenosine deaminases acting on RNA
  2. Chi-square test for genotype distribution