Patient stratum | Disease progression |
---|---|
Pre-colectomy | • ≥25 % increase in polyp burden (number, size) from baseline • Presence of large, sessile or ulcerated adenoma (not amenable to excision) • High-grade dysplasia • Large villous adenoma • In-situ or invasive cancer |
Retained rectum/ileal pouch polyposis | • ≥25 % increase in polyp burden (number, size) from baseline • Excisional intervention to remove any polyp ≥10 mm • High-grade dysplasia in any polyp • In-situ or invasive cancer on any biopsy |
Duodenal polyposis | • Increase in Spigelman Stage (2–4) from baseline • Need for excisional intervention • Development of cancer • Death (endoscopy/intervention related) |