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Fig. 4 | BMC Gastroenterology

Fig. 4

From: Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome

Fig. 4

TLR-4 protein expression in ileal and left colon mucosa of HC and IBS-D patients. TLR-4 protein baseline levels were higher in PI-IBS D patients in respect to HC in both ileal and colonic mucosa. The stimulation of intestinal mucosa with 100 μg/ml LPS increased TLR-4 protein expression in both HC and IBS-D patients with a more pronounced effect in colonic mucosa. LC-DG and PB treatment reduced TLR-4 protein expression in both HC and IBS-D patients particularly in ileal mucosa. ***p < 0.0001. HC: healthy controls; PI IBS-D: post-infectious irritable bowel disease diarrhea subtype; LPS: lipopolysaccharide; LC: Lactobacillus Casei DG; PB: postbiotic

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