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Table 3 Factors associated with new onset proteinuriaa (n = 455)

From: Proteinuria and baseline renal function predict mortality and renal outcomes after sirolimus therapy in liver transplantation recipients

 

Crude

Adjusted

Variable

HR (95%CI)

P value

HR (95%CI)

P value

Age at initiation, year

 50-64 vs 17-49

1.16 (0.76 − 1.75)

0.04

1.05 (0.68 − 1.62)

0.84

 ≥65 vs 17-49

2.22 (1.19 − 4.15)

0.04

1.75 (0.90 − 3.39)

0.10

Male vs female patients

0.61 (0.42 − 0.90)

0.02

0.67 (0.42 − 1.06)

0.09

Baseline eGFR < 60 vs ≥60 mL/min/1.73 m2

1.62 (1.15 − 2.27)

0.006

1.28 (0.89 − 1.85)

0.18

Hepatitis B

1.02 (0.72 − 1.44)

0.63

1.23 (0.78 − 1.95)

0.37

Hepatitis C

1.30 (0.90 − 1.87)

0.02

1.26 (0.80 − 1.97)

0.32

Alcoholism

0.64 (0.36 − 1.14)

0.74

0.79 (0.42 − 1.47)

0.45

Decompensated liver cirrhosis

1.24 (0.89 − 1.74)

0.20

1.21 (0.84 − 1.74)

0.32

HCC

1.02 (0.73 − 1.44)

0.29

1.06 (0.72 − 1.57)

0.76

Diabetes mellitus

2.32 (1.64 − 3.28)

<.0001

1.91 (1.32 − 2.77)

<.001

New onset diabetes mellitusb

2.77 (1.96 − 3.90)

<.0001

2.34 (1.62 − 3.38)

<.0001

CNI prior use

2.30 (0.73 − 7.27)

0.15

2.27 (0.69 − 7.43)

0.18

CNI use after

0.69 (0.32 − 1.48)

0.33

0.67 (0.29 − 1.54)

0.35

SRL trough level < 3 months

0.97 (0.91 − 1.03)

0.30

1.01 (0.95 − 1.07)

0.81

  1. aEvent of new onset proteinuria was identified within 1 year during the follow-up among a subgroup of patients without proteinuria presence at baseline
  2. bNew onset diabetes mellitus anytime in the follow-up period