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Table 4 Factors associated with deterioration of renal functiona (n = 533)

From: Proteinuria and baseline renal function predict mortality and renal outcomes after sirolimus therapy in liver transplantation recipients

Variable

Baseline eGFR < 60 mL/min/1.73 m2

Baseline eGFR ≥ 60 mL/min/1.73 m2

 

Adjusted HR (95%CI)

P value

Adjusted HR (95%CI)

P value

Age at initiation, year

 50-64 vs 17-49

0.77 (0.29 − 2.05)

0.60

1.14 (0.66 − 1.95)

0.64

 ≥65 vs 17-49

1.08 (0.23 − 5.13)

0.92

1.20 (0.45 − 3.16)

0.72

Male vs female patients

0.82 (0.36 − 1.84)

0.61

0.35 (0.19 − 0.65)

0.001

Prior hepatitis B

0.48 (0.21 − 1.09)

0.08

0.83 (0.45 − 1.55)

0.56

Prior hepatitis C

1.43 (0.61 − 3.37)

0.40

0.93 (0.51 − 1.69)

0.80

Prior alcoholism

1.52 (0.61 − 3.77)

0.37

1.35 (0.72 − 2.54)

0.35

Prior decompensated liver cirrhosis

1.04 (0.50 − 2.17)

0.92

1.55 (0.97 − 2.46)

0.07

Prior HCC

0.66 (0.32 − 1.39)

0.28

1.85 (1.03 − 3.29)

0.04

Prior diabetes mellitus

0.95 (0.43 − 2.09)

0.89

1.20 (0.71 − 2.01)

0.50

New onset diabetes mellitus

1.47 (0.69 − 3.16)

0.32

0.63 (0.40 − 1.24)

0.23

Proteinuria at baseline

1.93 (0.87 − 4.29)

0.11

1.29 (0.70 − 2.39)

0.42

New onset proteinuria < 1 year

5.38 (2.49 − 11.62)

<.0001

3.12 (1.92 − 5.09)

<.0001

  1. aEvent of renal function reduction was either eGFR declined > 50%, start receiving chronic dialysis or renal transplantation; whichever comes first