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Table 2 Cost per unit and number of procedures for monitoring and injections/tablets for treatment of genotype 1 chronic hepatitis C according to different regimens recommended by the BMoH from 2011 to 2015

From: Micro-costing analysis of guideline-based treatment by direct-acting agents: the real-life case of hepatitis C management in Brazil

 

Cost per unit

PEG-RBV

PEG-RBV/BOC

PEG-RBV/TEL

SOF/DCV

SOF/SIM

 

US$

PPP$

n

n

n

n

n

Transient elastography

53.35

95.32

–

1

1

1

1

Liver biopsy

482.32

834.41

1

–

–

–

–

Blood analysis tests

 WBC. RBC and platelet

10.62

19.11

15

17

16

6

6

 Fasting glucose

4.86

8.75

6

6

6

6

6

 BUN/creatinine

4.84

8.70

15

16

15

6

6

 ALT

4.85

8.73

15

16

15

6

6

 AST

4.86

8.74

15

16

15

6

6

 Alkaline phosphatases

4.77

8.58

6

6

6

6

6

 GGT

4.83

8.69

6

6

6

6

6

 Total bilirubin

4.84

8.71

6

6

6

6

6

 Albumin

5.07

9.12

6

6

6

6

6

 INR

6.68

12.02

6

13

14

6

6

 HCV genotype

156.33

281.22

1

1

1

1

1

 HCV-RNA

87.05

156.60

8

7

7

2

2

 TSH

26.26

47.23

6

6

6

–

–

 Beta-hCG

45.52

81.88

4

4

4

4

4

Medical follow-up

 GP’s medical visit

54.54

98.11

1

1

1

1

1

 Specialist’s medical visit

62.92

113.19

14

14

14

5

5

 Blood sample collection

37.83

68.06

15

15

15

6

6

 Nursing consultation

31.83

57.26

5

5

5

4

4

Drugs

 PEG-IFN α-2a 180 mcg – SC injection

360.22

648.00

48

48

48

–

–

 Ribavirin 250 mg – PO capsule

1.68

3.03

1680

1680

1680

–

–

 Boceprevir 200 mg – PO tablet

4.42

7.96

–

3612

–

–

–

 Telaprevir 375 mg – PO tablet

48.37

87.01

–

–

504

–

–

 Sofosbuvir 400 mg – PO tablet

80.54

144.89

–

–

–

84

84

 Daclastavir 60 mg – PO tablet

30.87

55.54

–

–

–

84

–

 Simeprevir 150 mg - PO tablet

42.98

77.32

–

–

–

–

84

  1. Costs in United States Dollars (US$) and with purchasing power parity (PPP$) on July 2015. Drug costs estimated as the weighted-mean price (http://www.saude.gov.br/bps)
  2. BOC boceprevir, DCV daclastavir, PEG-IFN peginterferon, RBV ribavirin, SIM simeprevir, SOF sofosbuvir, TEL telaprevir, WBC white blood cell, RBC red blood cell, BUN blood urea nitrogen, ALT alanine aminotransferase, AST aspartate aminotransferase, AP alkaline phosphatases, GGT gamma-glutamyl transpeptidase, INR international normalized ratio, TSH thyroid-stimulating hormone, hCG human chorionic gonadotropin, GP general practicioner
  3. Treatment regimens according to BMoH guidelines: PEG-RBV 48w [BMoH-2011]; PEG-RBV (48w)/BOC 44w [BMoH-2013A]; PEG-RBV (48w)/TEL (12w) [BMoH-2013B]; SOF/DCV 12w [BMoH-2015A] and SOF/SIM 12w [BMoH-2015B]