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Table 4 Multivariate Cox porportional hazard model for clinical relapse with off-therapy HBsAg level as a time-varying variable

From: Time-varying serum gradient of hepatitis B surface antigen predicts risk of relapses after off-NA therapy

Variables

Adjusted HR

95% CI

P

Time-varying HBsAg level, log IU/mL

2.32

1.28, 4.21

0.005

Male sex

1.05

0.33, 3.29

0.94

EOT age, year

1.03

1.00, 1.06

0.045

EOT ALT, U/L

1.03

1.02, 1.05

<0.0001

EOT AFP, ng/mL

0.88

0.67, 1.15

0.34

EOT anti-HBe-seropositive

1.27

0.14, 11.60

0.84

Pretreatment viral DNA, log IU/mL

1.03

0.79, 1.36

0.81

Pretreatment HBeAg-positive

0.46

0.66, 3.21

0.43

Pretreatment anti-HBe-positive

0.47

0.70, 3.20

0.44

  1. Notes. AFP alpha-fetoprotein, ALT Alanine transaminase, CI confidence interval, EOT end-of-therapy, HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HR hazard ratio