Table 2 Definitions of major complication
Major complication | Definition | Comment |
|---|---|---|
New-onset organ failure | New-onset failure (i.e., not present at any time in the 24 h before first intervention); Multiple-organ failure: failure of two or more organs at the same time. | |
Organ failure | Adapted from Bradley [24] | |
Pulmonary failure | PaO2 < 60 mmHg, despite FIO2of 0.30, or need for mechanical ventilation. | |
Circulatory failure | Circulatory systolic blood pressure < 90 mmHg, despite adequate fluid resuscitation, or need for inotropic catecholamine support. | |
Renal failure | Creatinine level > 177 μmol/l after rehydration or new need for hemofiltration or hemodialysis. | |
Systemic complication | Adapted from Bradley | |
Gastrointestinal bleeding | > 500 ml of blood/24 h | |
Intra-abdominal bleeding | Requiring surgical, radiologic, or endoscopic intervention. | |
Intestinal fistula | Secretion of fecal material from a percutaneous drain or inflow into the necrotic cavity, either from small or large bowel; confirmed by endscopy, imaging or during surgery. |