Fig. 1
From: Upcoming pharmacological developments in chronic hepatitis B: can we glimpse a cure on the horizon?
HBV Life cycle and therapeutic targets. The colour dots represent different drugs that work in many stages of the life cycle: a Binding HBV to NCTP receptor and endocytosis. b Uncoating nucleocapsid protein and release into cytosol. c Nuclear transport and bind to cell nucleus. d Shell of capsid disintegration and release of RNA. e rcDNA conversion to cccDNA. f Transcription. g RNA exportation from cell nucleus to cytosol. h Translation. i HBx stops transcription silence. j New nucleocapsids formed with RNA. k DNA synthesis from RNA (Target of Nucleos(t)ide analogues). l Nucleocapsid envelopment in Golgi apparatus. m HBsAg + HBeAg secretion and new viral particle