Table 6 Histopathological findings of the five patients with unexplained chronic liver disease who underwent liver biopsy
From: Unexplained chronic liver disease in Ethiopia: a cross-sectional study
No | Sex | Age (yr) | General microscopy | Parenchymal changes | Ishak-score |
|---|---|---|---|---|---|
1 | Female | 26 | Mild portal and lobular hepatitis with sinusoidal lymphocytosis. Variation of hepatic cord thickness. Normal bile ducts and intact liver plate. | Focal adaptive parenchymal changes with diffuse hepatocyte swelling/ clarification. No steatosis or haemosiderosis. Collagen proportionate area: 5% Proliferation index: 8% Apoptosis index: 3% | Fibrosis = 2 Necroinflammation = 2 • piecemeal 0 • lobular 1 • confluent 0 • portal 1 |
2 | Male | 25 | Normal architecture with normal portal areas, no inflammation. Normal bile ducts and intact liver plate. | Adaptive parenchymal changes with diffuse hepatocyte swelling/ clarification. No steatosis or haemosiderosis. Collagen proportionate area: 6% Proliferation index: 12% Apoptosis index: 5% | Fibrosis = 1 Necroinflammation = 0 |
3 | Female | 30 | Normal architecture with normal portal areas, no inflammation. Normal bile ducts and intact liver plate. | Mild adaptive parenchymal changes with diffuse hepatocyte swelling/clarification. No steatosis or haemosiderosis. Collagen proportionate area: 3% Proliferation index: 6% Apoptosis index: 1% | Fibrosis = 1 Necroinflammation = 1 • piecemeal 0 • lobular 1 • confluent 0 • portal 0 |
4 | Male | 25 | Normal architecture with normal portal areas, no inflammation. Normal bile ducts and intact liver plate. | Adaptive parenchymal changes with diffuse hepatocyte swelling/clarification. No steatosis or haemosiderosis. Collagen proportionate area: 8% Proliferation index: 15% Apoptosis index: 6% | Fibrosis = 0 Necroinflammation = 0 |
5 | Female | 25 | Normal architecture with normal portal areas. Normal bile ducts and intact liver plate | Mild mixed steatosis ≈ 20% Focal single cell necrosis, a few apoptotic hepatocytes, a few parenchymal granulocytes. No adaptive changes. Collagen proportionate area: 3% Proliferation index: 3% Apoptosis index: 2% | Fibrosis = 0 Necroinflammation = 1 • piecemeal 0 • lobular 1 • confluent 0 • portal 0 |