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Table 3 Clinical, laboratory and liver biopsy findings in patients with NAFLD with and without dysmetabolic iron overload syndrome (DIOS), and normal vs. elevated serum ferritin, respectively

From: Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease

 

NAFLD without DIOS (n = 22)

NAFLD with DIOS

(n = 16)

With serum ferritin < 350 μg/L (n = 15)

With serum ferritin > 350 μg/L (n = 7)

Serum hepcidin (μg/L)

24 ± 19

37 ± 13

53 ± 28*

Serum ferritin (μg/L)

156 ± 78*

621 ± 170

816 ± 285

Transferrin saturation (%)

28 ± 8

25 ± 10

39 ± 9#

Liver iron score

0.03 ± 0.13

0.14 ± 0.24

2.13 ± 0.92*

CRP (mg/L)

2.7 ± 2.2

3.7 ± 4.2

1.8 ± 0.91

Plasma-triglycerides (mmol/L)

2.89 ± 1.09

1.83 ± 1.09

1.95 ± 0.90

Plasma cholesterol (mmol/L)

5.18 ± 0.96

5.25 ± 0.84

5.25 ± 0.71

TNF-α (ng/L)

6.27 ± 5.13

137 ± 316

8.37 ± 5.82

IL-6 (ng/L)

2.47 ± 1.71

32.3 ± 62.7

2.36 ± 1.02

NAS

4.5 ± 1.8

3.6 ± 1.7

4.4 ± 1.8

Steatosis (grade)

2.07 ± 0.80

2.00 ± 1.00

2.72 ± 0.65

Ballooning

1.07 ± 0.59

0.80 ± 0.84

0.63 ± 0.67

Lobular inflammation

1.20 ± 0.86

1.00 ± 0.71

1.00 ± 1.00

Portal inflammation

0.27 ± 0.46

0.60 ± 0.55

0.18 ± 0.40

Fibrosis

1.33 ± 0.90

2.00 ± 1.00

2.72 ± 0.65

  1. Values denote mean ± S.D
  2. *=p < 0.05 (vs. the other groups)
  3. # = p < 0.05 (vs. NAFLD with serum ferritin > 350 μg/L)