Fig. 6
From: Secreted protein acidic and rich in cysteine-like 1 suppresses metastasis in gastric stromal tumors
Downregulation of SPARCL1 in GIST 882 cells promoted liver metastasis in xenograft mouse models. a Representative images of hematoxylin and eosin staining (HE × 100) and IHC staining (× 600) of SPARCL1 in xenografted tumors; b, c Quantification of tumor volume and tumor weight for tumorigenesis among three groups in nude mice (P > 0.05). The error bars refer to SD (n = 7, 8, and 5 for normal control, Lv-shNC and Lv-shSPARCL1, respectively); d Expression level of SPARCL1 mRNA was significantly decreased in Lv-shSPARCL1 group as compared to other two groups (*P < 0.05). The error bars present SD (n = 7, 8, and 5 for normal control, Lv-shNC and Lv-shSPARCL1, respectively); e Representative of gross view of liver without and with metastasis, and HE staining of liver metastatic tumor (M); f Low expression of SPARCL1 in liver metastatic nodules was observed in Lv-shSPARCL1 group as compared to other two groups; g The number of liver metastatic nodules was increased in Lv-shSPARCL1 group when compared to other two groups (*P < 0.05); h The relative SPARCL1 mRNA level of liver metastatic nodules of nude mice (*P < 0.05). The error bars refer to SD from the mean