Table 2 Determinants of biologic treatment and regression results
From: Biologic treatment of Japanese patients with inflammatory bowel disease
Characteristics | Overall, ORs, (95%CI) | Crohn’s disease, ORs (95%CI) | Ulcer Colitis, ORs (95%CI) |
|---|---|---|---|
Age (reference ≤40 years) | |||
41–65 years | 0.59 (0.37–0.93) | 0.41 (0.17–0.95) | 0.86 (0.42–1.74) |
> 65 years | 0.24 (0.09–0.65) | 0.37 (0.05–2.85) | 0.31 (0.08–1.26) |
Gender (reference male) | |||
Female | 0.77 (0.46–1.29) | 0.30 (0.11–0.79) | 1.67 (0.77–3.63) |
Marriage status (reference married) | |||
Single | 0.68 (0.41–1.10) | 0.87 (0.37–2.04) | 1.29 (0.60–2.81) |
Highest Education (reference college or less) | |||
Bachelor’s degree | 0.76 (0.49–1.18) | 0.51 (0.22–1.19) | 1.01 (0.51–2.02) |
Master’s degree and higher | 0.26 (0.10–0.71) | 0.06 (0.01–0.41) | 1.45 (0.41–5.16) |
Occupation | |||
Fulltime | 2.74 (0.43–7.13) | 0.38 (0.01–1.17) | 2.38 (0.25–3.00) |
Part-time | 2.16 (0.32–4.70) | 0.28 (0.01–1.07) | 1.57 (0.14–17.08) |
Self employed | 2.39 (0.34–6.52) | 0.21 (0.01–7.28) | 3.21 (0.28–6.28) |
House wife | 3.24 (0.46–2.52) | 0.25 (0.01–1.69) | 1.95 (0.17–2.24) |
Student | 5.20 (0.30–9.37) | 0 (Omitted) | 0 (Omitted) |
Unemployed/Pensioner | 3.50 (0.54–2.65) | 0.77 (0.02–5.11) | 2.44 (0.22–6.58) |
Household incomes (reference less than 2 M JPY) | |||
2–4 M JPY | 1.26 (0.55–2.87) | 0.25 (0.06–1.03) | 1.49 (0.40–5.59) |
4–6 M JPY | 1.56 (0.69–3.56) | 1.04 (0.28–3.86) | 1.16 (0.29–4.56) |
6–8 M JPY | 1.50 (0.62–3.61) | 1.98 (0.45–8.83) | 0.74 (0.17–3.22) |
8–10 M JPY | 1.43 (0.51–4.01) | 0.84 (0.17–4.27) | 0.57 (0.08–4.09) |
> 10 M JPY | 1.24 (0.45–3.41) | 1.05 (0.18–6.02) | 0.51 (0.09–2.71) |
Comorbidity | |||
Dyslipidemia | 0.55 (0.23–1.34) | 0.73 (0.13–3.96) | 0.36 (0.09–1.56) |
Hypertension | 0.85 (0.42–1.72) | 0.41 (0.11–1.60) | 1.20 (0.44–3.28) |
COPD Asthma | 1.70 (0.62–4.61) | 3.32 (0.39–8.54) | 2.00 (0.53–7.57) |
Diabetes | 1.42 (0.60–3.33) | 0.97 (0.15–6.34) | 2.48 (0.80–7.64) |
Depression | 0.64 (0.27–1.49) | 0.49 (0.10–2.30) | 0.61 (0.16–2.36) |
OA and RA | 1.27 (0.29–5.52) | 0.41 (0.04–4.45) | 2.44 (0.24–24.85) |
Gastrointestinal disease | 1.03 (0.41–2.57) | 0.69 (0.10–4.55) | 1.39 (0.39–4.93) |
Surgical history | |||
Previous surgical history | 1.98 (1.24–3.16) | 1.15 (0.53–2.47) | 0.82 (0.28–2.36) |
Current treatment | |||
Nutritional | 3.16 (2.00–5.12) | 1.90 (0.87–4.12) | 2.42 (1.00–5.89) |
5-ASA | 0.89 (0.54–1.49) | 1.05 (0.46–2.39) | 1.24 (0.46–3.35) |
Steroid | 1.04 (0.61–1.78) | 2.25 (0.81–6.26) | 1.19 (0.56–2.56) |
Immunosuppressant | 3.15 (1.94–5.12) | 1.44 (0.62–3.28) | 4.61 (2.25–9.45) |
Cytapheresis | 1.23 (0.33–4.64) | 0 (Omitted) | 2.00 (0.41–9.68) |
Time since diagnosis (reference 0–2 years) | |||
3–8 years | 3.63 (1.69–7.76) | 1.48 (0.33–6.54) | 4.27 (1.33–3.72) |
9–15 years | 3.26 (1.42–7.45) | 1.10 (0.22–5.52) | 3.99 (1.13–4.13) |
> 15 years | 4.16 (1.80–9.56) | 0.92 (0.20–4.28) | 3.95 (1.04–4.90) |
Type of hospitals (reference university hospital) | |||
General/Specialist hospital | 0.62 (0.40–0.96) | 1.09 (0.50–2.34) | 0.41 (0.19–0.84) |
Clinics | 0.47 (0.24–0.89) | 0.42 (0.10–1.79) | 0.43 (0.17–1.09) |
Frequency of visit (Reference less than once in a month) | |||
Once every month | 0.91 (0.45–1.84) | 1.56 (0.47–5.22) | 0.58 (0.22–1.56) |
Once every 2 months | 1.83 (0.88–3.82) | 14.36 (3.98–51.83) | 0.50 (0.17–1.45) |
Once every 3 months | 0.09 (0.03–0.27) | 0.26 (0.05–1.21) | 0.03 (0.01–0.29) |
Less than every 3 months | 0 (Omitted) | 0 (Omitted) | 0 (Omitted) |