Factor | Category | Univariate | (95% CI) | P value* | Multivariate | (95% CI) | P value* |
---|---|---|---|---|---|---|---|
Hazard ratio | Hazard ratio | ||||||
Demographic data | |||||||
Gender | Male | 1 | 1 | ||||
Female | 5.59 | (2.07–15.1) | 0.001 | 5.83 | (1.47–23.1) | 0.012 | |
Age | < 70 y | 1 | |||||
≥70 y | 0.05 | (0.00–5618) | 0.606 | ||||
Body mass index | < 25.0 kg/m2 | 1 | |||||
≥25.0 kg/m2 | 1.41 | (0.56–3.57) | 0.472 | ||||
Hypertension | Absence | 1 | |||||
Presence | 1.53 | (0.62–3.77) | 0.357 | ||||
Hyperlipidemia | Absence | 1 | |||||
Presence | 1.20 | (0.43–3.56) | 0.732 | ||||
Histological findings | |||||||
Steatosis | 5–33% | 1 | 1 | ||||
> 33% | 3.30 | (1.09–10.0) | 0.035 | 9.52 | (1.57–57.6) | 0.014 | |
Lobular inflammation | < 2 foci per 200× field | 1 | |||||
≥2 foci per 200× field | 1.70 | (0.63–4.57) | 0.296 | ||||
Ballooning | None / Few cells | 1 | |||||
Many cells | 0.57 | (0.13–2.49) | 0.452 | ||||
Stage | 0–3 | 1 | |||||
4 | 1.47 | (0.20–11.0) | 0.711 | ||||
NAFLD activity score | < 5 | 1 | |||||
≥5 | 1.30 | (0.51–3.26) | 0.583 | ||||
Diagnosis according to FLIP algorithm | non-NASH | 1 | |||||
NASH | 1.42 | (0.41–4.90) | 0.579 | ||||
Laboratory data | |||||||
Serum aspartate aminotransferase | < 2 × ULN IU/l | 1 | |||||
≥2 × ULN IU/l | 1.19 | (0.45–3.13) | 0.730 | ||||
Serum alanine aminotransferase | < 2 × ULN IU/l | 1 | |||||
≥2 × ULN IU/l | 1.47 | (0.59–3.64) | 0.408 | ||||
Gamma-glutamyl transpeptidase | < 110 IU/l | 1 | |||||
≥110 IU/l | 0.28 | (0.08–0.96) | 0.043 | ||||
Platelet count | < 200 × 103/mm3 | 1 | |||||
≥200 × 103/mm3 | 1.94 | (0.64–5.87) | 0.239 | ||||
Fasting plasma glucose | < 110 mg/dl | 1 | |||||
≥110 mg/dl | 1.31 | (0.37–4.62) | 0.672 | ||||
HbA1c | < 5.8% | 1 | |||||
≥5.8% | 2.33 | (0.32–16.9) | 0.404 | ||||
Uric acid | < 7.1 mg/dl | 1 | |||||
≥7.1 mg/dl | 1.28 | (0.49–3.38) | 0.615 | ||||
Total cholesterol | < 200 mg/dl | 1 | |||||
≥200 mg/dl | 2.43 | (0.80–7.34) | 0.116 | ||||
Triglycerides | < 150 mg/dl | 1 | |||||
≥150 mg/dl | 0.78 | (0.31–1.97) | 0.594 | ||||
High-density lipoprotein cholesterol | < 41 mg/dl | 1 | |||||
≥41 mg/dl | 0.49 | (0.20–1.20) | 0.117 | ||||
Low-density lipoprotein cholesterol | < 136 mg/dl | 1 | |||||
≥136 mg/dl | 3.20 | (1.06–9.69) | 0.040 | ||||
Serum ferritin | < 81 μg/l | 1 | 1 | ||||
≥81 μg/l | 0.26 | (0.10–0.70) | 0.008 | 0.18 | (0.06–0.56) | 0.003 | |
High sensitive C-reactive protein | < 0.2 mg/dl | 1 | |||||
≥0.2 mg/dl | 1.84 | (0.57–5.97) | 0.312 | ||||
Alpha-fetoprotein | < 5 μg/l | 1 | |||||
≥5 μg/l | 1.08 | (0.38–3.04) | 0.887 | ||||
PIVKA-II | < 21 AU/l | 1 | |||||
≥21 AU/l | 0.23 | (0.03–1.79) | 0.160 |