Table 3 Diagnostic performances of combinations of four serum biomarkers for differentiating HCC from liver disease
Markers | AUC | Sensitivity (Sn) | Specificity (Sp) | Sn + Sp | PPV | NPV |
|---|---|---|---|---|---|---|
AFP + NLR | 0.769 (0.732–0.802) | 0.767 (0.721–0.807) | 0.773 (0.705–0.828) | 1.54 | 0.876 (0.836–0.908) | 0.613 (0.547–0.674) |
AFP + ALT | 0.697 (0.657–0.734) | 0.639 (0.578–0.677) | 0.841 (0.780–0.888) | 1.48 | 0.892 (0.849–0.924) | 0.519 (0.461–0.577) |
AFP + AST | 0.749 (0.711–0.783) | 0.884 (0.847–0.912) | 0.466 (0.394–0.540) | 1.35 | 0.776 (0.734–0.813) | 0.656 (0.569–0.734) |
ALT+AST | 0.694 (0.654–0.731) | 0.802 (0.759–0.840) | 0.470 (0.394–0.540) | 1.272 | 0.759 (0.714–0.799) | 0.529 (0.451–0.606) |
NLR + ALT | 0.653 (0.612–0.692) | 0.596 (0.545–0.645) | 0.773 (0.705–0.828) | 1.369 | 0.846 (0.797–0.885) | 0.477 (0.420–0.535) |
NLR + AST | 0.736 (0.697–0.771) | 0.892 (0.856–0.919) | 0.409 (0.339–0.483) | 1.301 | 0.760 (0.717–0.798) | 0.643 (0.551–0.726) |
AFP + AST + ALT | 0.749 (0.711–0.783) | 0.884 (0.847–0.912) | 0.466 (0.394–0.540) | 1.35 | 0.776 (0.734–0.813) | 0.656 (0.569–0.734) |
NLR + AST + ALT | 0.736 (0.697–0.771) | 0.892 (0.856–0.919) | 0.409 (0.339–0.483) | 1.301 | 0.760 (0.717–0.798) | 0.643 (0.551–0.726) |
AFP + NLR + ALT | 0.773 (0.735–0.806) | 0.791 (0.747–0.830) | 0.733 (0.663–0.793) | 1.524 | 0.861 (0.821–0.894) | 0.626 (0.558–0.689) |
AFP + NLR + AST | 0.760 (0.722–0.796) | 0.927 (0.896–0.949) | 0.409 (0.339–0.483) | 1.336 | 0.767 (0.725–0.804) | 0.727 (0.632–0.805) |
AFP + AST + ALT+NLR | 0.760 (0.722–0.796) | 0.927 (0.896–0.949) | 0.409 (0.339–0.483) | 1.336 | 0.767 (0.725–0.804) | 0.727 (0.632–0.805) |