Table 2 Univariate and multivariate Cox regression analyses in patients with acute decompensation of CHB cirrhosis from the derivation cohort (n = 509)
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |
Age (yr) | 1.054(1.031–1.079) | < 0.001 | 1.057(1.032–1.082) | < 0.001 |
Male sex | 2.350(1.391–3.969) | < 0.001 | ||
Mean arterial pressure (mm Hg) | 0.979(0.953–1.005) | 0.116 | ||
Previous decompensation | 2.419(1.420–4.120) | 0.001 | 2.449(1.351–4.438) | 0.002 |
Complication | ||||
Hyponatremia | 4.005(2.351–6.823) | < 0.001 | ||
Ascites | 0.463(0.113–1.900) | < 0.001 | ||
Bacteria infection | 2.479(1.443–4.259) | 0.001 | 5.325(3.015–9.405) | < 0.001 |
Gastrointestinal hemorrhage | 2.301(1.042–5.081) | 0.039 | ||
Hepatic encephalopathy I-II | 1.426(0.439–4.631) | 0.555 | ||
Hepatic encephalopathy III-IV | 22.381(10.893–45.983) | < 0.001 | 4.660(3.115–6.972) | < 0.001 |
Spontaneous bacterial peritonitis | 4.392(1.988–9.703) | < 0.001 | ||
Hepatorenal syndrome | 6.345(3.617–11.129) | < 0.001 | ||
Organ failures | ||||
Liver | 2.720(1.583–4.672) | < 0.001 | ||
Kidney | 4.839(2.370–9.881) | < 0.001 | ||
Cerebral | 20.324(10.909–37.863) | < 0.001 | ||
Coagulation | 9.389(5.547–16.891) | < 0.001 | ||
Circulation | 10.148(3.657–28.166) | < 0.001 | ||
Lung | 9.706(3.024–31.154) | < 0.001 | ||
Biochemical parameters | ||||
Alanine aminotransferase (U/L) | 1.000(1.000–1.001) | 0.298 | ||
Aspartate aminotransferase (U/L) | 1.001(1.000–1.002) | 0.005 | ||
γ-Glutamyltransferase (U/L) | 0.999(0.996–1.003) | 0.722 | ||
Albumin (g/L) | 0.937(0.890–0.987) | 0.015 | ||
Total bilirubin (mg/dL) | 1.048(1.029–1.067) | < 0.001 | 1.053(1.030–1.078) | < 0.001 |
Serum creatinine (μmol/L) | 1.005(1.003–1.007) | < 0.001 | ||
Serum sodium (mmol/L) | 0.904(0.872–0.937) | < 0.001 | ||
International normalized ratio | 1.963(1.683–2.290) | < 0.001 | ||
White blood cell count (×109/L) | 1.151(1.108–1.195) | < 0.001 | ||
Neutrophil count (×109/L) | 1.175(1.128–1.225) | < 0.001 | ||
Platelet (× 109/L) | 0.998(0.993–1.004) | 0.576 | ||
HBV-DNA (log copies/ml) | 1.160(0.986–1.366) | 0.074 | ||