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Table 3 Association measures according to variables of interest

From: Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer

Variable

Cases

Controls

ORa (95% CIb) not adjusted

OR (95% CI) ajusted

P-value

IL-4 -590 (C/T) SNP (%)

n = 15

n = 20

   

 Mutatedc

12 (80.0)

18 (90.0)

0.44 (0.06–3.07)

0.21 (0.02–2.20)

0.195

 Wild

3 (20.0)

2 (10.0)

IL-4 Ile50Val SNP (%)

n = 17

n = 30

   

 Mutated

(0.00)

(0.00)

dnad

dna

1.000

 Wild

17 (100.0)

30(100.0)

IL-4 Q576R SNP (%)

n = 17

n = 30

   

 Mutated

7 (41.2)

13 (43.3)

0.91 (0.17–3.01)

1.40 (0.37–5.57)

0.601

 Wild

10 (58.8)

17 (56.7)

IL-10 -592(A/C) SNP (%)

n = 16

n = 29

   

 Homozygous for mutation

8 (50.0)

14 (48.3)

1.00 (0.32–3.63)

1.00 (0.29–3.77)

0.949

 Heterozygous

8 (50.0)

15 (51.7)

IL-10 -819(T/C) SNP (%)

n = 17

n = 30

   

 Mutated

14 (93.3)

27 (90.0)

1.55 (0.15–16.37)

1.50 (0.13–17.18)

0.740

 Wild

1 (6.7)

3 (10.0)

IL-10 -1082 (G/A) SNP (%)

n = 12

n = 12

   

 Mutated

6 (50.0)

3 (25.0)

3.00 (0.56–16.89)

7.58 (0.77–74.06)

0.080

 Wild

6 (50.0)

9 (75.0)

IL-4/IL-4Rα SNPs (%)

n = 17

n = 30

   

 (≥ 2 mutations)

5 (29.4)

7 (23.3)

1.37 (0.36–5.24)

1.35 (0.34–5.37)

0.673

 (<  2 mutations)

12 (70.6)

23 (76.7)

IL-10 Haplotype (%)

n = 16

n = 30

   

 (≥ 2 mutations)

14 (87.5)

26 (86.7)

1.08 (0.17–6.63)

1.08 (0.15–7.42)

0.940

 (<  2 mutations)

2 (12.5)

4 (13.3)

  1. aOdds ratio; b Confidence interval; c Mutated (heterozygous, homozygous) d Does not apply