Characteristics | Healthy subjects | Prednisolone (n = 17) | Infliximab (n = 21) | |||
---|---|---|---|---|---|---|
Day 0 | Day 7 | Day 0 | Day 7 | P Group, day 0 | ||
Ulcerative colitis/ Crohn’s disease (n) | 13/4 | 7/14 | 0.008 | |||
Age (years) | 34.4 ± 8.9 | 30.5 ± 11.0 | 0.243 | |||
Male/female (n) | 10/7 | 10/11 | 0.492 | |||
BMI (kg/m2) | 23.3 ± 4.5 | 25.1 ± 5.8 | 0.306 | |||
SCCAI | 9 (7;10) | 2 (1;2)** | 8 (5;9) | 2 (1;4)* | 0.537 | |
HBI | 8 (5;13) | 4 (1;6)* | 5.5 (3;8) | 2 (1;3)** | 0.243 | |
eGFR | 98 (70;104) | 94 (89;101) | 102 (94;122) | 101 (93;114) | 0.008 | |
CRP (mg/L) | 12.8 (3.6;21.5) | 7.2 (3.5;21.2)** | 7.2 (3.5;21.2) | 2.7 (1.4;7.9)* | 0.587 | |
ESR (mm/h) | 14 (7;27) | 6 (5;10)** | 13.5 (8.5;19.5) | 11 (7;16)* | 0.647 | |
Orosomucoid (g/L) | 1.4 ± 0.4 | 1.2 ± 0.5* | 1.3 ± 0.4 | 1.0 ± 0.3** | 0.383 | |
Calprotectin (mg/kg) | 2072 ± 1254 | 1100 ± 1124** | 1569 ± 1099 | 810 ± 777** | 0.311 | |
Cortisol (μg/L) | 129 (107;255) | 435 (27;941) | 125 (104;154) | 129 (110;141) | 0.364 | |
Insulin (pmol/L) | 44 ± 38 | 42 ± 17 | 45 ± 25 | 49 ± 26 | 0.865 | |
TNF-α (ng/L) | 1.5 ± 1.0 | 1.1 ± 1.9 | 1.1 ± 0.9 | 11.5 ± 6.0** | 0.173 | |
IL-6 (ng/L) | 2.9 ± 2.6 | 1.6 ± 1.5* | 2.8 ± 1.6 | 1.7 ± 1.7* | 0.973 | |
IGF-I (μg/L) | 128 ± 36 | 185 ± 67** | 159 ± 33 | 178 ± 50* | 0.009 | |
IGF-II (μg/L) | 502 ± 61 | 502 ± 60 | 495 ± 71 | 518 ± 75* | 0.746 | |
IGF bioactivity (μg/L) | 1.08 ± 0.36 | 1.34 ± 0.52* | 1.23 ± 0.42 | 1.33 ± 0.45 | 0.260 | |
IGFBP-3 (μg/L) | 4120 ± 583 | 4332 ± 771 | 4220 ± 687 | 4417 ± 687* | 0.638 | |
IGFBP-4 (μg/L) | 174 ± 79 | 184 (146;315) | 132 (111;188)* | 183 (152;207) | 164 (97;209)* | 0.410 |
CT-IGFBP-4 (μg/L) | 72 ± 18 | 112 ± 33† | 79 ± 41** | 99 ± 35† | 78 ± 35** | 0.246 |
CT-IGFBP-4/IGFBP-4 ratio | 0.41 (0.29;0.53) | 0.61 ± 0.27† | 0.57 ± 0.35† | 0.55 ± 0.15† | 0.59 ± 0.36† | 0.443 |
NT-IGFBP-4 (μg/L) | 153 ± 41 | 257 ± 111† | 179 ± 93** | 207 ± 76† | 170 ± 78** | 0.108 |
NT-IGFBP-4/IGFBP-4 ratio | 0.80 (0.61;0.99) | 1.34 ± 0.57† | 1.28 ± 0.72† | 1.16 ± 0.31† | 1.30 ± 0.84† | 0.223 |
PAPP-A (μg/L) | 0.81 ± 0.26 | 1.17 ± 0.66† | 1.21 ± 0.56† | 0.76 ± 0.37 | 0.87 ± 0.33* | 0.019 |
STC2 (μg/L) | 25.0 (21.2;28.1) | 22.2 ± 5.2 | 21.5 ± 4.8 | 22.9 ± 5.6 | 24.3 ± 7.6 | 0.698 |