Table 1 Classification criteria of clinical, CTE and GIUS evaluations

Clinical evaluation

Healing of all ulcers; or complete mucosal healing^a of over 50% lesion area compared to the baseline colonoscopy; or mucosal healing of less than 50% lesion area, but over 50% decrease of hsCRP levels, plus over 50% symptom improvement [19]

Improvements in some manifestations but cannot reach the “good response” criteria

No improvement in any manifestations

CTE evaluation

Lesion area decreased over 50% compared to previous CTE; or lesion area decreased less than 50%, plus a significant decrease in bowel wall thickness, less bowel wall enhancement and smaller lymph nodes

Improvements in some manifestations but cannot reach the “good response” criteria^b

No improvement in any CTE manifestations

GIUS evaluation

Lesion area decreased over 50% compared to previous GIUS; or lesion area decreased less than 50%, plus Limberg score decreased at least two grades [20]

Improvements in some manifestations but cannot reach the “good response” criteria

No improvement in any US manifestations