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Table 5 Treatments five to one year before or one year after hospitalisation with a diagnosis of IBS in France in 2015 according to ATC code and the number of reimbursements of some drugs

From: Healthcare use by 30,000 patients with irritable bowel syndrome (IBS) in France: a 5-year retrospective and one-year prospective national observational study

 

Before hospitalisation

After hospitalisation

Year

−5

−4

−3

−2

−1 year

+ 1 year

Age

All

All

All

All

All*

18–39

40–59

60–74

75 +

All*

18–39

40–59

60–74

75 +

Drugs (ATC code)

%

%

%

%

%

%

%

%

%

%

%

%

%

%

Drugs for functional GI disorders (A03)

 0 reimbursement

14.7

17.5

21.2

26.5

34.8

27.0

35.4

40.4

36.9

48.9

42.5

49.5

53.9

49.0

 1–2

24.0

26.4

29.0

32.4

35.4

39.5

36.8

31.6

29.1

33.1

37.7

33.7

29.3

28.8

 3 or more

61.3

56.1

49.8

41.1

29.7

33.5

27.8

28.0

34.1

18.0

19.8

16.8

16.8

22.2

Drugs for functional GI disorders (A03A)

 0

19.7

22.8

26.8

32.3

40.7

32.1

41.0

47.0

44.4

53.9

47.3

54.1

59.1

55.0

 1–2

29.2

31.0

32.8

34.8

36.0

42.8

37.0

30.8

28.5

32.3

38.2

32.9

27.7

27.3

 3 or more

51.1

46.2

40.5

32.9

23.2

25.1

22.0

22.2

27.1

13.8

14.5

13.0

13.1

17.7

Antispasmodics or anticholinergics in combination with other drugs (A03C-D-E)

 0

80.2

82.0

84.1

86.2

89.1

88.7

89.0

89.2

89.8

92.4

92.3

92.3

92.7

92.6

 1–2

15.3

14.2

12.9

11.5

9.5

10.4

9.8

8.9

7.8

6.8

7.3

7.1

6.3

5.9

 3 or more

4.6

3.8

3.1

2.2

1.4

0.9

1.2

1.8

2.4

0.7

0.4

0.6

0.9

1.6

Propulsives (A03F)

 0

54.9

61.0

67.2

74.7

82.8

76.9

84.3

85.7

82.4

89.8

86.7

90.8

91.2

89.1

 1–2

30.6

28.2

25.0

20.4

15.0

20.8

14.0

11.9

13.0

9.3

12.4

8.6

7.8

9.1

 3 or more

14.5

10.9

7.8

4.9

2.3

2.2

1.7

2.4

4.6

0.9

0.8

0.6

1.1

1.8

Laxatives (A06)

 0

4.8

5.2

5.8

6.7

7.8

9.4

5.5

6.4

19.4

11.3

12.4

8.8

9.8

24.7

 1–2

57.9

61.3

64.7

68.3

72.6

75.5

76.7

72.0

46.0

74.9

77.1

78.7

74.9

50.8

 3 or more

37.3

33.5

29.5

25.0

19.6

15.1

17.8

21.6

34.5

13.8

10.5

12.5

15.3

24.5

Laxatives (A06)a

 0

33.7

35.9

38.6

41.8

46.2

48.2

46.9

45.4

39.8

52.0

53.6

52.6

51.0

47.6

 1–2

38.2

38.7

39.2

39.6

39.9

42.5

41.2

38.8

30.4

38.9

40.3

39.5

38.5

33.0

 3 or more

28.1

25.3

22.1

18.5

13.9

9.4

11.9

15.9

29.8

9.1

6.1

7.9

10.5

19.4

Softeners, emollients (A06AA)

 0

92.7

93.4

94.2

95.1

96.2

96.8

96.6

96.1

93.2

97.3

97.9

97.6

97.3

94.7

 1–2

5.7

5.2

4.6

3.9

3.1

2.9

2.8

2.9

5.0

2.2

2.0

2.0

2.2

4.2

 3 or more

1.6

1.4

1.2

1.0

0.7

0.2

0.6

0.9

1.8

0.4

0.2

0.3

0.6

1.2

Contact laxatives (A06AB)

 0

72.9

73.4

74.1

74.7

75.0

73.5

73.7

75.1

85.4

75.9

74.3

74.7

76.0

86.0

 1–2

26.9

26.4

25.8

25.3

24.9

26.4

26.2

24.9

14.5

24.1

25.6

25.3

24.0

13.9

 3 or more

0.2

0.1

0.1

0.0

0.0

0.0

0.0

0.0

0.1

0.0

0.0

0.0

0.0

0.0

Bulk-forming laxatives (A06AC)

 0

85.0

86.4

88.1

89.6

91.7

92.8

91.9

91.4

88.2

93.6

94.5

93.7

93.3

91.8

 1–2

10.7

9.9

8.8

7.9

6.7

6.5

6.9

6.1

8.0

5.5

5.1

5.7

5.3

6.3

 3 or more

4.3

3.7

3.1

2.4

1.7

0.7

1.2

2.6

3.8

0.9

0.4

0.7

1.4

1.9

Osmotically acting laxatives (A06AD)

 0

17.1

18.7

20.2

22.0

24.4

28.0

22.4

22.6

29.8

28.5

31.5

26.4

26.6

35.9

 1–2

58.3

60.0

61.4

62.9

64.5

65.0

68.0

64.8

45.8

64.5

64.0

67.8

65.1

48.3

 3 or more

24.6

21.3

18.4

15.1

11.0

7.0

9.5

12.6

24.4

7.0

4.5

5.9

8.3

15.8

Enemas (A06AG)

 0

84.0

85.4

86.9

88.5

90.4

89.5

91.4

91.0

86.5

92.2

91.4

92.9

92.8

89.4

 1–2

14.4

13.3

12.2

10.8

9.2

10.3

8.3

8.5

12.5

7.6

8.4

7.0

7.0

10.1

 3 or more

1.6

1.3

1.0

0.7

0.4

0.3

0.2

0.5

1.0

0.2

0.2

0.1

0.2

0.5

Antidiarrheals, intestinal antiinflammatory/antiinfective agents (A07)

 0

51.2

55.7

60.6

67.0

75.0

67.6

77.7

78.5

71.7

82.3

77.1

84.4

85.0

77.7

 1–2

31.6

30.0

27.8

24.5

19.6

27.4

17.6

16.0

19.1

14.7

20.2

12.9

11.9

16.2

 3 or more

17.1

14.3

11.6

8.4

5.4

5.0

4.7

5.5

9.2

3.1

2.6

2.7

3.1

6.1

Antipropulsives (A07D)

 0

68.4

72.0

75.6

80.1

85.2

82.7

86.6

86.4

80.9

89.7

88.2

90.8

90.7

85.2

 1–2

23.1

21.0

18.6

15.6

12.1

15.4

10.9

10.5

14.1

8.8

10.9

7.8

7.7

11.7

 3 or more

8.5

7.0

5.7

4.2

2.7

1.9

2.5

3.1

5.0

1.5

1.0

1.4

1.6

3.1

Other antidiarrheals (A07X)

 0

69.7

72.9

76.5

81.0

86.3

80.6

88.0

89.4

84.7

90.7

86.9

91.8

92.8

88.6

 1–2

24.6

22.4

20.0

16.8

12.5

18.3

11.0

9.5

13.3

8.8

12.5

7.7

6.6

10.3

 3 or more

5.7

4.6

3.4

2.2

1.1

1.2

1.0

1.1

2.0

0.6

0.5

0.5

0.6

1.1

Antidepressants

 0 reimbursement

63.9

66.9

70.2

73.8

78.7

86.1

77.6

76.2

71.2

83.1

89.7

82.3

80.6

76.1

 1–2

10.3

9.4

8.4

7.4

5.9

6.3

6.0

5.0

6.5

6.4

5.2

6.6

6.6

8.0

 3 or more

25.8

23.7

21.5

18.8

15.4

7.6

16.3

18.7

22.3

10.5

5.2

11.0

12.8

15.8

Neuroleptics

 0

92.8

93.6

94.3

95.3

96.4

97.3

96.1

96.5

95.3

97.2

98.0

96.9

97.2

96.2

 1–2

2.8

2.4

2.1

1.6

1.1

1.1

1.2

0.9

1.6

1.2

0.9

1.2

1.2

1.8

 3 or more

4.4

4.0

3.6

3.1

2.5

1.7

2.7

2.6

3.2

1.6

1.1

1.9

1.6

2.0

Anxiolytics

 0

42.1

46.2

51.2

57.6

67.5

74.5

66.8

65.4

58.1

76.6

83.1

76.5

74.0

66.7

 1–2

23.8

23.2

22.1

20.2

16.0

17.7

17.3

13.9

12.2

13.3

12.4

13.8

13.1

14.0

 3 or more

34.1

30.6

26.7

22.3

16.4

7.9

15.9

20.6

29.7

10.1

4.5

9.6

12.8

19.3

Hypnotics

 0

72.1

74.8

78.0

81.5

86.0

93.5

86.0

82.1

77.8

89.7

95.6

90.0

86.2

82.6

 1–2

12.2

11.1

9.6

8.1

6.0

4.1

6.8

6.5

5.7

5.4

2.8

5.5

7.0

7.3

 3 or more

15.7

14.1

12.4

10.4

8.0

2.4

7.3

11.4

16.4

4.9

1.6

4.4

6.7

10.1

  1. aexcluding drugs indicated for purge in a context of colonoscopy preparation
  2. *P < 0.0001 for distribution comparisons between “all −1 year” vs “all 1 year”