Demographics | CIMP-1 (≥4/5) | CIMP-2 (≥3/5) | CIMP-3 (≥5/8) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Positive (8.5%) | Negative | P | Positive (12%) | Negative | P | High (10.2%) | Low (77.3%) | Negative (12.5%) | P | |
Age | Â | Â | 0.1871 | Â | Â | 0.1108 | Â | Â | Â | 0.0296 |
≤49 | 15 (3.7%) | 108 (26.9%) |  | 22 (5.5%) | 101 (25.2%) |  | 20 (5%) | 86 (21.4%) | 17 (4.2%) |  |
50–59 | 11 (2.7%) | 135 (33.7%) |  | 14 (3.5%) | 132 (32.9%) |  | 11 (2.7%) | 120 (29.9%) | 15 (3.7%) |  |
≥60 | 8 (2%) | 124 (30.9%) |  | 12 (3%) | 120 (29.9%) |  | 10 (2.5%) | 104 (25.9%) | 18 (4.5%) |  |
Gender | Â | Â | 0.0046 | Â | Â | 0.0063 | Â | Â | Â | 0.0011 |
Men | 11 (2.7%) | 217 (54.1%) | Â | 18 (4.5%) | 210 (52.4%) | Â | 13 (3.2%) | 186 (46.4%) | 29 (7.2%) | Â |
Women | 23 (5.7%) | 150 (37.4%) | Â | 30 (7.5%) | 143 (35.7%) | Â | 28 (7%) | 124 (30.9%) | 21 (5.2%) | Â |
Tumor location | Â | Â | 0.0142 | Â | Â | 0.0552 | Â | Â | Â | 0.0065 |
Distal | 19 (4.7%) | 281 (70.1%) | Â | 30 (7.5%) | 270 (67.3%) | Â | 23 (5.7%) | 244 (60.8%) | 33 (8.2%) | Â |
Proximal | 15 (3.7%) | 86 (21.4%) | Â | 18 (4.5%) | 83 (20.7%) | Â | 18 (4.5%) | 66 (16.5%) | 17 (4.2%) | Â |
Stage | Â | Â | 0.1697 | Â | Â | 0.5059 | Â | Â | Â | 0.5459 |
I | 5 (1.2%) | 72 (18.0%) | Â | 9 (2.2%) | 68 (17%) | Â | 6 (1.5%) | 61 (15.2%) | 10 (2.5%) | Â |
II | 17 (4.2%) | 144 (35.9%) | Â | 24 (6%) | 137 (34.2%) | Â | 21 (5.2%) | 119 (29.7%) | 21 (5.2%) | Â |
III | 9 (2.2%) | 139 (34.7%) | Â | 14 (3.5%) | 134 (33.4%) | Â | 13 (3.2%) | 120 (29.9%) | 15 (3.7%) | Â |
IV | 3 (0.7%) | 12 (3.0%) | Â | 1 (0.2%) | 14 (3.5%) | Â | 1 (0.2%) | 10 (2.5%) | 4 (1%) | Â |
BRAF status | Â | Â | 0.2339 | Â | Â | 0.039 | Â | Â | Â | 0.2771 |
Wild type | 33 (8.2%) | 365 (91.0%) | Â | 46 (11.5%) | 352 (87.8%) | Â | 40 (10%) | 308 (76.8%) | 50 (12.5%) | |
Mutation | 1 (0.2%) | 2 (0.5%) | Â | 2 (0.5%) | 1 (0.2%) | Â | 1 (0.2%) | 2 (0.5%) | 0 (0) | Â |
KRAS status | Â | Â | 0.0957 | Â | Â | 0.1072 | Â | Â | Â | 0.1033 |
Wild type | 21 (5.2%) | 280 (69.8%) | Â | 31 (7.7%) | 270 (67.3%) | Â | 26 (6.5%) | 234 (58.4%) | 41 (10.2%) | |
Mutation | 13 (3.2%) | 87 (21.7%) | Â | 17 (4.2%) | 83 (20.7%) | Â | 15 (3.7%) | 76 (19%) | 9 (2.2%) | Â |
MSI status | Â | Â | 1 | Â | Â | 0.287 | Â | Â | Â | 0.7373 |
MSS | 5 (6.1%) | 53 (64.6%) | Â | 10 (12.2%) | 48 (58.5%) | Â | 8 (9.8%) | 44 (53.7%) | 6 (7.3%) | Â |
MSI-low | 1 (1.2%) | 18 (22.0%) | Â | 2 (2.4%) | 17 (20.7%) | Â | 2 (2.4%) | 15 (18.3%) | 2 (2.4%) | Â |
MSI-high | 0 (0) | 5 (6.1%) | Â | 2 (2.4%) | 3 (3.7%) | Â | 1 (1.2%) | 4 (4.9%) | 0 (0) | Â |