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Table 2 Clinicopathologic and molecular characteristics of CRCs

From: Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer

Demographics

CIMP-1 (≥4/5)

CIMP-2 (≥3/5)

CIMP-3 (≥5/8)

Positive (8.5%)

Negative

P

Positive (12%)

Negative

P

High (10.2%)

Low (77.3%)

Negative (12.5%)

P

Age

  

0.1871

  

0.1108

   

0.0296

≤49

15 (3.7%)

108 (26.9%)

 

22 (5.5%)

101 (25.2%)

 

20 (5%)

86 (21.4%)

17 (4.2%)

 

50–59

11 (2.7%)

135 (33.7%)

 

14 (3.5%)

132 (32.9%)

 

11 (2.7%)

120 (29.9%)

15 (3.7%)

 

≥60

8 (2%)

124 (30.9%)

 

12 (3%)

120 (29.9%)

 

10 (2.5%)

104 (25.9%)

18 (4.5%)

 

Gender

  

0.0046

  

0.0063

   

0.0011

Men

11 (2.7%)

217 (54.1%)

 

18 (4.5%)

210 (52.4%)

 

13 (3.2%)

186 (46.4%)

29 (7.2%)

 

Women

23 (5.7%)

150 (37.4%)

 

30 (7.5%)

143 (35.7%)

 

28 (7%)

124 (30.9%)

21 (5.2%)

 

Tumor location

  

0.0142

  

0.0552

   

0.0065

Distal

19 (4.7%)

281 (70.1%)

 

30 (7.5%)

270 (67.3%)

 

23 (5.7%)

244 (60.8%)

33 (8.2%)

 

Proximal

15 (3.7%)

86 (21.4%)

 

18 (4.5%)

83 (20.7%)

 

18 (4.5%)

66 (16.5%)

17 (4.2%)

 

Stage

  

0.1697

  

0.5059

   

0.5459

I

5 (1.2%)

72 (18.0%)

 

9 (2.2%)

68 (17%)

 

6 (1.5%)

61 (15.2%)

10 (2.5%)

 

II

17 (4.2%)

144 (35.9%)

 

24 (6%)

137 (34.2%)

 

21 (5.2%)

119 (29.7%)

21 (5.2%)

 

III

9 (2.2%)

139 (34.7%)

 

14 (3.5%)

134 (33.4%)

 

13 (3.2%)

120 (29.9%)

15 (3.7%)

 

IV

3 (0.7%)

12 (3.0%)

 

1 (0.2%)

14 (3.5%)

 

1 (0.2%)

10 (2.5%)

4 (1%)

 

BRAF status

  

0.2339

  

0.039

   

0.2771

Wild type

33 (8.2%)

365 (91.0%)

 

46 (11.5%)

352 (87.8%)

 

40 (10%)

308 (76.8%)

50 (12.5%)

Mutation

1 (0.2%)

2 (0.5%)

 

2 (0.5%)

1 (0.2%)

 

1 (0.2%)

2 (0.5%)

0 (0)

 

KRAS status

  

0.0957

  

0.1072

   

0.1033

Wild type

21 (5.2%)

280 (69.8%)

 

31 (7.7%)

270 (67.3%)

 

26 (6.5%)

234 (58.4%)

41 (10.2%)

Mutation

13 (3.2%)

87 (21.7%)

 

17 (4.2%)

83 (20.7%)

 

15 (3.7%)

76 (19%)

9 (2.2%)

 

MSI status

  

1

  

0.287

   

0.7373

MSS

5 (6.1%)

53 (64.6%)

 

10 (12.2%)

48 (58.5%)

 

8 (9.8%)

44 (53.7%)

6 (7.3%)

 

MSI-low

1 (1.2%)

18 (22.0%)

 

2 (2.4%)

17 (20.7%)

 

2 (2.4%)

15 (18.3%)

2 (2.4%)

 

MSI-high

0 (0)

5 (6.1%)

 

2 (2.4%)

3 (3.7%)

 

1 (1.2%)

4 (4.9%)

0 (0)

 
  1. Bold P value indicates P ≤ 0.05