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Fig. 3 | BMC Gastroenterology

Fig. 3

From: Stress ulcer prophylaxis with proton pump inhibitors or histamine 2 receptor antagonists in critically ill adults - a meta-analysis of randomized controlled trials with trial sequential analysis

Fig. 3

Trial sequential analysis for the clinically important GI bleeding. Trial sequential analysis using random-effects model with a relative risk reduction of 20%, an adjusted type I error of 3.3%, power of 80%. (panel a) In all trials reported data on the clinically important GI bleeding, control event proportion of 4.6%, D2 of 25% (the actual measured D2 was 0%), the cumulative Z-curve cross no boundaries, the required information size of 22,114 patients are not reached. The TSA-adjusted 95% CI for an RR of 0.58 is 0.23 to1.51. (panel b) In trials with low risk of bias, control event proportion of 4.1%, D2 of 25% (the actual measured D2 was 0%), the cumulative Z-curve cross no boundaries, the required information size of 24,928 patients are not reached. The TSA-adjusted 95% CI for an RR of 0.64 is 0.15 to 2.80. (panel c) In trials with use of EN, control event proportion of 4.2%, D2 of 25% (the actual measured D2 was 0%), the cumulative Z-curve cross no boundaries, the required information size of 24,310 patients are not reached. The TSA-adjusted 95% CI for an RR of 0.61 is 0.16 to 2.38. SUP stress ulcer prophylaxis; GI gastrointestinal; TSA trial sequential analysis; EN enteral nutrition

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BMC Gastroenterology

ISSN: 1471-230X

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