Stress ulcer prophylaxis with proton pump inhibitors or histamine 2 receptor antagonists in critically ill adults - a meta-analysis of randomized controlled trials with trial sequential analysis

Table 2 Assessment of the risk of bias of each included trials

First author /Publication year	Adequate Sequence Generation	AllocationConcealment	Blinding of participants and personnel	Blinding of outcome assessment	Incomplete Outcome Data	Selective reporting	Other Bias	Overall risk of bias
Alhazzani/2017	L	L	L	L	L	L	L	L
Apte/1992	unclear	unclear	H	unclear	L	L	H	H
Basso/1981	L	unclear	H	L	H	H	unclear	H
Ben-Menachem/1994	L	L	H	L	H	L	L	H
van den Berg /1985	unclear	unclear	L	L	L	H	L	H
Burgess/1995	L	unclear	L	L	H	L	unclear	H
Calvet/1998	unclear	L	L	L	L	H	L	H
Darlong/2003	unclear	unclear	H	unclear	H	H	L	H
El-Kersh/2018	L	L	L	L	L	L	L	L
Friedman/1982	unclear	unclear	L	L	L	H	H	H
Groll/1986	unclear	unclear	L	L	L	L	H	H
Gursoy/2008	L	unclear	L	L	L	L	L	H
Halloran/1980	L	unclear	L	L	L	L	H	H
Hanisch/1998	L	L	L	L	L	L	L	L
Kantorova/2004	L	L	unclear	L	L	L	unclear	H
Karlstadt/1990	unclear	unclear	L	L	L	L	unclear	H
Krag/2018	L	L	L	L	L	L	L	L
Lin/2016	unclear	unclear	unclear	unclear	L	L	L	H
Liu/2013	L	unclear	unclear	unclear	L	L	unclear	H
Macdougall/1977	unclear	unclear	H	H	L	L	unclear	H
Martin/1993	unclear	unclear	L	L	L	L	H	H
Metz/1993	L	L	L	L	L	H	H	H
Nourian/2018	L	unclear	unclear	unclear	L	L	L	H
Peura/1985	unclear	unclear	L	L	L	L	L	H
Powell/1993	H	H	H	unclear	L	L	L	H
Reusser/1990	unclear	unclear	H	unclear	L	L	L	H
Ruiz-Santana/1991	unclear	unclear	H	H	H	L	L	H
Selvanderan/2016	L	unclear	L	L	L	L	L	H
Zinner/1981	L	H	H	unclear	H	unclear	L	H

ISSN: 1471-230X