Effectiveness, benefit harm and cost effectiveness of colorectal cancer screening in Austria

BMC Gastroenterology

Table 3 Comparative individual fact box for benefits and harms (per person)

Outcome:	10-yearly Colonoscopy	Annual FIT	Differences FIT vs. Colonoscopy
Life-weeks gained^a	21	26	5
Probability of dying from CRC (%)	0.8	0.3	− 0.5
Probability of developing CRC (%)	2.2	1.4	−0.8
Mean number of complications due to colonoscopy (hospital admissions)	0.0012	0.0012	0
Mean number of positive test results	0.7	2.2	1.5

Numbers pertain to an individual average 40 years of age who were followed until death. Full adherence to screening strategies including follow-up and surveillance tests was assumed. ^ain comparison to No Screening, CRC - colorectal cancer, FIT - fecal immunochemical test screening strategy. FIT: 40–75 years old average - risk men and women. Colonoscopy: 50–70 years old average - risk men and women, all screening strategies include index testing, further diagnostics (including colonoscopy), surveillance (colonoscopy), treatment and follow up interventions; annual guaiac-fecal occult blood test screening strategy is dominated by annual FIT in benefit harm analysis and, therefore, not included in table.

ISSN: 1471-230X