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Table 1 Literatures of the effects of the CONUT score in patients undergoing hepatectomy for hepatocellular carcinoma

From: Prognostic significance of the controlling nutritional status (CONUT) score in patients undergoing hepatectomy for hepatocellular carcinoma: a systematic review and meta-analysis

Study

Year

Country

Study design

Number (Male)

Tumor stage

Cut-off for high CONUT group

Prevalence of high CONUT score

End points

Qualitya

Takagi et al. [11]

2017

Japan

Retrospective Single center

295 (241)

I: 36

II: 126

III: 92

IV: 41

≥3

40.0%

OS

RFS

7

Harimoto et al. [12]

2017

Japan

Retrospective Single center

357 (270)

I: 58

II: 187

III: 93

IV: 19

≥4

19.3%

OS

RFS

6

Takagi et al. [13]

2018

Japan

Retrospective Single center

331 (269)

I + II: 185

III + IV: 146

≥5

9.1%

Complications

6

Harimoto et al. [14]

2018

Japan

Retrospective Multi-center

2461 (1785)

I + II: 1437

III + IV: 1024

≥4

21.9%

OS

RFS

6

Li et al. [15]

2018

China

Retrospective Single center

1334 (1136)

n.a.

≥8b

49.4%

Complications

8

Wang et al. [16]

2018

China

Retrospective Single center

209 (172)

BCLC stage A: 126

B: 40

C: 43

≥3

34.5%

OS

RFS

PHR

6

Lin et al. [17]

2019

China

Retrospective Single center

380 (333)

I + II: 304

III + IV: 76

≥2

49.2%

OS

RFS

8

  1. aScore from a maximum of 9 evaluated by the Newcastle–Ottawa quality assessment scale for cohort studies [8].
  2. bEvaluated by postoperative CONUT score
  3. CONUT controlling nutritional status, OS overall survival, RFS recurrence-free survival, n.a not available, BCLC stage Barcelona clinic liver cancer stage, PHR postoperative hepatitis B virus reactivation