a) | CD8+ CD28- CD57+ (as % of CD8+) | CD8+ Memory (as % of CD8+) | CD8+ Naïve (as % of CD8+) | CD8+ Naïve:Memory ratio | ||||
Unadjusted Mean Difference (95% CI) | P-value | Unadjusted Mean Difference (95% CI) | P-value | Unadjusted Mean Difference (95% CI) | P-value | Unadjusted Ratio of Meansa (95% CI) | P-value | |
No advanced fibrosis/ cirrhosis | 1 (referent group) | 1 (referent group) | 1 (referent group) | 1 (referent group) | ||||
Advanced fibrosis/ cirrhosis | 0.67 (−6.15, 7.48) | 0.85 | −2.61 (−8.59, 3.36) | 0.39 | 2.48 (−3.78, 8.73) | 0.44 | 1.24 (0.84, 1.90) | 0.25 |
b) | CD8+ CD28- CD57+ (as %CD8+) | CD8+ Memory (as %CD8+) | CD8+ Naïve (as%CD8+) | CD8+ Naïve:Memory ratio | ||||
Adjusted Mean Difference (95% CI) | P-value | Adjusted Mean Difference (95% CI) | P-value | Adjusted Mean Difference (95% CI) | P-value | Adjusted Mean Difference (95% CI) | P-value | |
No advanced fibrosis/ cirrhosis | 1 (referent group) | 1 (referent group) | 1 (referent group) | 1 (referent group) | ||||
Advanced fibrosis/ cirrhosis (adjusted) | −0.36 (−7.35, 6.63) | 0.92 | −3.16 (−8.90, 2.57) | 0.28 | 3.07 (−2.97, 9.11) | 0.32 | 1.32 (0.88, 1.97) | 0.18 |
Age/years | −0.07 (− 0.39, 0.53) | 0.77 | − 0.15 (− 0.53, 0.23) | 0.45 | 0.01 (− 0.39, 0.41) | 0.96 | 1.00 (0.97, 1.03) | 0.96 |
Female sex | −0.53 (−6.93, 5.87) | 0.87 | −3.12 (− 8.37, 2.13) | 0.24 | 2.76 (−2.76, 8.29) | 0.33 | 1.23 (0.85, 1.78) | 0.27 |
Log10(HIV-1 RNA copies/mL) | −0.18 (−2.70, 2.34) | 0.89 | 2.94 (0.87, 5.01) | < 0.01 | −2.38 (−4.55, − 0.20) | 0.03 | 0.91 (0.79, 1.05) | 0.20 |
Heavy drinking | −0.15 (−9.45, 9.16) | 0.98 | −6.68 (−14.32, 0.95) | 0.09 | 8.27 (0.23, 16.30) | 0.04 | 1.47 (0.86, 2.51) | 0.16 |
Injection drug use | 3.26 (−3.08, 9.60) | 0.31 | −1.10 (−6.31, 4.10) | 0.68 | 2.95 (−2.53, 8.42) | 0.29 | 1.26 (0.87, 1.81) | 0.22 |
Current smoking | −0.17 (−8.51, 8.18) | 0.97 | 5.31 (−1.53, 12.16) | 0.13 | −5.58 (− 12.79, 1.63) | 0.13 | 0.74 (0.46, 1.20) | 0.23 |
Years since HIV diagnosis | −0.16 (− 0.72, 0.41) | 0.59 | − 0.24 (− 0.70, 0.22) | 0.31 | 0.65 (0.16, 1.14) | < 0.01 | 1.03 (1.00, 1.07) | 0.07 |
Hepatitis C | 6.67 (−2.29, 15.63) | 0.14 | 1.5 (−5.84, 8.86) | 0.69 | −2.93 (−10.7, 4.81) | 0.46 | 0.89 (0.53, 1.48) | 0.65 |
Hepatitis B | −3.41 (−9.68, 2.86) | 0.29 | 4.72 (−0.42, 9.87) | 0.07 | −5.55 (−11.0, − 0.13) | 0.04 | 0.67 (0.47, 0.97) | 0.03 |
Shingles | 1.70 (−5.02, 8.43) | 0.62 | 3.04 (−2.48, 8.55) | 0.28 | −1.64 (−7.44, 4.17) | 0.58 | 0.85 (0.58, 1.25) | 0.41 |
Tuberculosis | 2.43 (−6.07, 10.93) | 0.58 | −8.60 (−15.57, − 1.62) | 0.02 | 6.07 (− 1.27, 13.41) | 0.11 | 1.46 (0.89, 2.37) | 0.13 |