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Table 4 a) Unadjusted and b)adjusted association between liver fibrosis status and CD8+ T-cell subsets reflecting immunosenesence among art-naïve PLWHA with recent heavy alcohol use

From: Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study

a)

CD8+ CD28- CD57+ (as % of CD8+)

CD8+ Memory (as % of CD8+)

CD8+ Naïve (as % of CD8+)

CD8+ Naïve:Memory ratio

Unadjusted Mean Difference (95% CI)

P-value

Unadjusted Mean Difference (95% CI)

P-value

Unadjusted Mean Difference (95% CI)

P-value

Unadjusted Ratio of Meansa (95% CI)

P-value

No advanced fibrosis/ cirrhosis

1 (referent group)

 

1 (referent group)

 

1 (referent group)

 

1 (referent group)

 

Advanced fibrosis/ cirrhosis

0.67 (−6.15, 7.48)

0.85

−2.61 (−8.59, 3.36)

0.39

2.48 (−3.78, 8.73)

0.44

1.24 (0.84, 1.90)

0.25

b)

CD8+ CD28- CD57+ (as %CD8+)

CD8+ Memory (as %CD8+)

CD8+ Naïve (as%CD8+)

CD8+ Naïve:Memory ratio

Adjusted Mean Difference (95% CI)

P-value

Adjusted Mean Difference (95% CI)

P-value

Adjusted Mean Difference (95% CI)

P-value

Adjusted Mean Difference (95% CI)

P-value

No advanced fibrosis/ cirrhosis

1 (referent group)

 

1 (referent group)

 

1 (referent group)

 

1 (referent group)

 

Advanced fibrosis/ cirrhosis (adjusted)

−0.36 (−7.35, 6.63)

0.92

−3.16 (−8.90, 2.57)

0.28

3.07 (−2.97, 9.11)

0.32

1.32 (0.88, 1.97)

0.18

Age/years

−0.07 (− 0.39, 0.53)

0.77

− 0.15 (− 0.53, 0.23)

0.45

0.01 (− 0.39, 0.41)

0.96

1.00 (0.97, 1.03)

0.96

Female sex

−0.53 (−6.93, 5.87)

0.87

−3.12 (− 8.37, 2.13)

0.24

2.76 (−2.76, 8.29)

0.33

1.23 (0.85, 1.78)

0.27

Log10(HIV-1 RNA copies/mL)

−0.18 (−2.70, 2.34)

0.89

2.94 (0.87, 5.01)

< 0.01

−2.38 (−4.55, − 0.20)

0.03

0.91 (0.79, 1.05)

0.20

Heavy drinking

−0.15 (−9.45, 9.16)

0.98

−6.68 (−14.32, 0.95)

0.09

8.27 (0.23, 16.30)

0.04

1.47 (0.86, 2.51)

0.16

Injection drug use

3.26 (−3.08, 9.60)

0.31

−1.10 (−6.31, 4.10)

0.68

2.95 (−2.53, 8.42)

0.29

1.26 (0.87, 1.81)

0.22

Current smoking

−0.17 (−8.51, 8.18)

0.97

5.31 (−1.53, 12.16)

0.13

−5.58 (− 12.79, 1.63)

0.13

0.74 (0.46, 1.20)

0.23

Years since HIV diagnosis

−0.16 (− 0.72, 0.41)

0.59

− 0.24 (− 0.70, 0.22)

0.31

0.65 (0.16, 1.14)

< 0.01

1.03 (1.00, 1.07)

0.07

Hepatitis C

6.67 (−2.29, 15.63)

0.14

1.5 (−5.84, 8.86)

0.69

−2.93 (−10.7, 4.81)

0.46

0.89 (0.53, 1.48)

0.65

Hepatitis B

−3.41 (−9.68, 2.86)

0.29

4.72 (−0.42, 9.87)

0.07

−5.55 (−11.0, − 0.13)

0.04

0.67 (0.47, 0.97)

0.03

Shingles

1.70 (−5.02, 8.43)

0.62

3.04 (−2.48, 8.55)

0.28

−1.64 (−7.44, 4.17)

0.58

0.85 (0.58, 1.25)

0.41

Tuberculosis

2.43 (−6.07, 10.93)

0.58

−8.60 (−15.57, − 1.62)

0.02

6.07 (− 1.27, 13.41)

0.11

1.46 (0.89, 2.37)

0.13

  1. aResult after back transformation from natural log scale