Table 6 Association between liver fibrosis status (continuous measure) and a) CD8+ T-cell b) CD4+ T-cell subsets reflecting immunosenesence among art-naïve PLWHA with recent heavy alcohol use
a) | CD8+ CD28- CD57+ (as % of CD8+) | |
Adjusted Mean Difference (95% CI) | P-value | |
Log(FIB-4) ≤ 1 | 6.2 (− 0.70, 13.18) | 0.08 |
Log(FIB-4) > 1 | −5.54 (− 13.6, 2.47) | 0.17 |
Age/years | −0.06 (− 0.58, 0.45) | 0.80 |
Female sex | −0.83 (−7.68, 6.01) | 0.81 |
Log10(HIV-1 RNA) | −0.45 (− 3.15, 2.25) | 0.74 |
Heavy drinking | 1.24 (−8.99, 11.47) | 0.81 |
Injection drug use | 3.54 (−3.12, 10.20) | 0.30 |
Current smoking | −0.55 (−9.53, 8.43) | 0.90 |
Years since HIV diagnosis | −0.08 (− 0.68, 0.52) | 0.79 |
Hepatitis C | 4.32 (−5.33, 13.97) | 0.38 |
Hepatitis B | −3.69 (− 10.34, 2.97) | 0.27 |
Shingles | 0.32 (−6.82, 7.46) | 0.93 |
Tuberculosis | 3.11 (−5.82, 12.04) | 0.49 |
b) | CD4+ CD28- CD57+ (as% of CD4+) | |
Adjusted Mean Difference (95% CI) | P-value | |
Log(FIB-4) | 0.99 (0.64, 1.54) | 0.97 |
Age/years | 1.05 (0.99, 1.10) | 0.09 |
Female sex | 0.83 (0.41, 1.71) | 0.62 |
Log10(HIV-1 RNA) | 0.90 (0.68, 1.20) | 0.48 |
Heavy drinking | 1.07 (0.37, 3.14) | 0.90 |
Injection drug use | 1.09 (0.54, 2.19) | 0.81 |
Current smoking | 0.89 (0.35, 2.27) | 0.80 |
Years since HIV diagnosis | 0.99 (0.93, 1.05) | 0.68 |
Hepatitis C | 0.34 (0.13, 0.93) | 0.04 |
Hepatitis B | 0.62 (0.31, 1.24) | 0.18 |
Shingles | 1.34 (0.63, 2.81) | 0.44 |
Tuberculosis | 0.92 (0.36, 2.36) | 0.87 |