Table 1 Comparison of patient characteristics between those taking and not taking NSBB at the initial visit for liver transplant evaluation. Values are shown as median (interquartile range) or number (percentage)
On NSBB n = 65 | Not on NSBB n = 105 | P value | |
|---|---|---|---|
Age, years | 58 (52–64) | 59 (53–63) | NS |
BMI | 28 (25–35) | 29 (25–35) | NS |
Male gender | 43 (66%) | 64 (64%) | NS |
Diabetes mellitus | 21 (32%) | 33 (32%) | NS |
Hypertension | 28 (43%) | 52 (50%) | NS |
Chronic kidney disease | 16 (25%) | 11 (11%) | .02 |
Heart rate beats/min | 66 (60–73) | 78 (70–88) | <.001 |
Mean arterial pressure, mmHg | 82 (76–93) | 86 (78–93) | NS |
Race | |||
Caucasian | 57 (88%) | 91 (87%) | NS |
Black | 3 (5%) | 7 (7%) | |
Hispanic | 4 (6%) | 5 (5%) | |
Other | 1 (1%) | 2 (2%) | |
Cirrhosis Etiology | |||
Hepatitis C | 27 (42%) | 57 (54%) | NS |
Alcohol | 23 (34%) | 31 (30%) | NS |
NASH | 20 (30%) | 22 (21%) | NS |
Child Pugh Score | 10 (9–11) | 9 (7–10) | .001 |
Child Pugh class | |||
A | 3 (5%) | 16 (15%) | .01 |
B | 24 (37%) | 50 (48%) | |
C | 38 (58%) | 39 (38%) | |
MELD | 16 (14–19) | 14 (10–19) | 0.03 |
INR | 1.5 (1.3–1.7) | 1.3 (1.2–1.6) | .04 |
Bilirubin mg/dL | 2.7 (2–3.7) | 1.9 (1.3–3.5) | .04 |
Creatinine mg/dL | 1.1 (0.8–1.4) | 0.9 (0.7–1.2) | .1 |
Albumin g/dL | 2.9 (2.5–3.1) | 3 (2.5–3.4) | NS |
Sodium | 135 (132–137) | 135 (131–138) | NS |
Esophageal varices | |||
None or small | 24 (37%) | 70 (71%) | <.001 |
Non-bleeding large | 21 (32%) | 19 (19%) | |
Prior bleeding | 20 (31%) | 13 (13%) | |
Gastric varices | |||
None or small | 61 (94%) | 100 (98%) | NS |
Non-bleeding large | 2 (3%) | None | |
Prior bleeding | 2 (3%) | 2 (2%) | |
Ascites | |||
None | 12 (18%) | 30 (30%) | NS |
Controlled | 35 (55%) | 53 (51%) | |
Refractory | 18 (27%) | 21 (20%) | |
Hepatic encephalopathy | |||
None | 18 (28%) | 41 (40%) | NS |
Controlled | 32 (48%) | 48 (47%) | |
Refractory | 15 (24%) | 14 (13%) | |
Transjugular Intrahepatic Portosystemic shunt | 5 (8%) | 13 (13%) | NS |
Cirrhosis complications | |||
Spontaneous bacterial peritonitis | 2 (3%) | 3 (3%) | NS |
Hepatorenal syndrome | 2 (3%) | 3 (3%) | NS |
Hepatopulmonary syndrome | None | 2 (2%) | NS |
Portopulmonary hypertension | 2 (3%) | 5 (5%) | NS |
Hepatocellular carcinoma | 10 (15%) | 26 (26%) | NS |
Acute kidney injury associated with hospitalization prior to liver transplant evaluation | 7 (11%) | 13 (13%) | NS |
NSBB indication | |||
Large or previously bleeding varices | 42 (65%) | 34 (32%) | <.001 |
NSBB contraindication (refractory ascites or spontaneous bacterial peritonitis) | 20 (31%) | 24 (23%) | NS |