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Fig. 1 | BMC Gastroenterology

Fig. 1

From: Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis

Fig. 1

Uric acid induces hepatocytes lipid accumulation both in vitro and in vivo. a Intracellular triglyceride contents were significantly increased in AML-12 cells after stimulating with uric acid for 48 h; b Representative images of Oil Red O staining of AML-12 cells (200×). c Serum uric acid level was significantly higher in HFD-fed mice than SCD-fed mice, and the level was decreased by allopurinol treatment in HFD + A group. d Intrahepatic triglyceride contents of the mice fed by different diets. f Representative images of liver histology determined by H & E and Oil Red O staining (× 200). Data are presented as the mean ± SD of at least three independent replicates. * P < 0.05, ** P < 0.01, *** P < 0.001 of two-tailed student’s t-test or ANOVA

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