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Table 4 Comparisons of demographics and baseline clinical characteristics of the patients in the derivation and validation cohort

From: A novel predictive model based on inflammatory markers to assess the prognosis of patients with HBV-related acute-on-chronic liver failure: a retrospective cohort study

Variables

Validation cohort(n = 156)

derivation cohort (n = 421)

P value

Age (years)

48.92 ± 11.94

47.93 ± 11.40

0.372

Gender (M: F)

129/27

365/56

Cirrhosis (%)

114(73.1%)

299(71.02%)

0.627

Bacterial infections

101(64.74%)

307(72.92%)

0.055

TBIL (μmol/L)

239.43 ± 136.17

323.39 ± 165.69

< 0.001

INR

1.92(1.58, 2.43)

2.25(1.86, 2.76)

< 0.001

Cr (μmol/L)

62.40(52.15, 80.35)

69.30(57.28, 87.90)

0.004

RDW (%)

16.10(14.50, 18.10)

15.90(14.38, 18.42)

0.842

MPV (FL)

11.29 ± 1.67

11.74 ± 1.53

0.003

NLR

4.33(2.68, 7.87)

4.84(3.19, 8.07)

< 0.001

MLR

0.61(0.41, 0.90)

0.64(0.42, 0.94)

0.473

GPR

0.91(0.53, 1.50)

0.97(0.59, 1.69)

0.162

RPR

0.17(0.11, 0.28)

0.19(0.12, 0.30)

0.093

MPR

0.70(0.59, 0.83)

0.14(0.09, 0.20)

< 0.001

PNI

35.03(30.65, 41.10)

34.10(30.20, 38.31)

0.033

PLR

95.92(63.99, 143.22)

91.03(62.69, 127.69)

0.206

RLR

17.77(11.73, 26.73)

16.70(3.71, 85.81)

0.939

MELD SCORE

21.41 ± 7.84

25.05 ± 6.75

< 0.001

MELD-Na

21.24 ± 15.66

24.32 ± 12.69

0.001

CTP

10.48 ± 1.89

11.09 ± 2.00

0.029

  1. TBIL total bilirubin, ALB albumin, γ-GGT gamma-glutamyl transpeptidase, Cr creatinine, Cyst-c Cystatin c, Serum Na + serum sodium, PT prothrombin time, INR international normalized ratio, PTA prothrombin activity, WBC white blood cell count, RDW red blood cell distribution width, NLR neutrophil/lymphocyte ratio, MLR monocyte/lymphocyte ratio, PLR platelet/lymphocyte ratio, RPR RDW/platelet ratio, GPR gamma-glutamyl transpeptidase/platelet ratio, MPV mean platelet volume, RLR RDW/lymphocyte ratio, PNI prognostic nutritional index, MPR MPV/platelet ratio, MELD model for end-stage liver disease, MELD-Na MELD-sodium score, CTP child-Turcotte Pugh score