Extra-hepatic comorbidity burden significantly increases 90-day mortality in patients with cirrhosis and high model for endstage liver disease

Table 2 The analysis of factors associated with 90-day mortality without liver transplant (LT) by Cox regression in 332 patients with cirrhosis referred for LT, 33 of whom died within 90 days of initial evaluation. Eight of 340 patients assessed underwent LT within 90-days from initial assessment and were excluded from this analysis

Factor	Univariable analysis			Multivariable analysis
Factor	Hazard ratio	95% confidence interval	p-value	Hazard ratio	95% confidence interval	P-value
CCI	1.2	(0.97–1.5)	0.09	1.33	(1.02–1.73)	0.037
MELD-Na	1.22	(1.16–1.29)	< 0.001	1.26	(1.18–1.33)	< 0.001
Age	1.01	(0.98–1.06)	0.5	1.02	(0.96–1.07)	0.5
Male gender	2.4	(1.03–5.4)	0.043	1.2	(0.5–3)	0.6
Body mass index	1.01	(0.96–1.07)	0.4	1.02	(0.96–1.09)	0.4
Race (reference white)
Black	2.2	(0.7–7.1)	0.2	2.9	(0.8–11)	0.12
Hispanic	1.9	(0.5–7.9)	0.4	0.4	(0.1–1.7)	0.19
Asian	NA^a			NA^a
Etiology liver disease (Reference alcohol)
Alcohol and viral	2.4	(0.7–8)	0.15	2.8	(0.8–9.8)	0.08
Viral	1.9	(0.6–6)	0.24	2.3	(0.7–7.8)	0.15
Autoimmune	NA^a			NA^a
Fatty liver	1.6	(0.5–5.5)	0.4	3.3	(0.8–14.3)	0.11
Cryptogenic	2.1	(0.2–18.8)	0.5	2.6	(0.2–31)	0.5
Hepatocellular carcinoma	1.4	(0.7–2.9)	0.4	2	(0.8–5)	0.11

Abbreviations: CCI Charlson Comorbidity Index (excluding liver disease and liver cancer), MELD-Na Model for End-stage Liver Disease with sodium modification, NA not applicable
Footnotes: ^a no patients in the analysis or with the endpoint to analyze

ISSN: 1471-230X