Skip to main content

Table 5 The association of individual components of the Charlson Comorbidity Index (excluding liver disease and liver cancer) and CIRCOM with 90-day and overall mortality in the unadjusted analyses

From: Extra-hepatic comorbidity burden significantly increases 90-day mortality in patients with cirrhosis and high model for endstage liver disease

Comorbid conditions

Analysis of 90-day mortality

n = 332

Analysis of overall mortality

n = 340

Patients with condition (%)

Hazard ratio

95% confidence interval

P-value

Patients with condition (%)

Sub-Hazard ratio

95% confidence interval

P-value

Myocardial infarctionb c

1.8

NAa

  

1.8

1.3

(0.8–2.2)

0.3

Coronary artery disease (no infarction)

18.4

0.4

(0.1–1.4)

0.17

18.5

1.1

(0.8–1.5)

0.7

Congestive heart failureb c

4.2

0.8

(0.1–5.6)

0.8

4.4

2

(1.4–2.9)

< 0.001

Peripheral vascular diseaseb c

3.3

NAa

  

3.2

1.1

(0.6–2.2)

0.7

Cerebrovascular diseaseb

2.7

1.2

(0.16–8.8)

0.9

2.7

2

(1.1–3.4)

0.015

Dementiab

0.9

4 (

0.5–29)

0.17

1.2

2

(0.5–7.6)

0.3

Chronic obstructive pulmonary diseaseb

15.1

1.5

(0.6–3.4)

0.3

13.5

1.6

(1.1–2.2)

0.007

Connective tissue diseaseb

3.6

3.1

(0.9–10)

0.06

3.8

1.9

(1.1–3.4)

0.03

Peptic ulcer diseaseb

6

1.7

(0.5–5.5)

0.4

5.3

1.5

(0.8–2.6)

0.2

Diabetes without complicationsb

23.8

0.6

(0.2–1.4)

0.2

24.4

0.95

(0.7–1.3)

0.8

Diabetes with complicationsb

8.1

0.7

(0.2–3)

0.2

7.9

1.6

(1.1–2.4)

0.016

Hemiplegiab

0.6

NAa

  

0.6

0.9

(0.1–6.1)

0.9

Renal disease (creatinine > 3 mg/dL)b

2.1

1.5

(0.2–11)

0.7

1.8

5.1

(0.9–30)

0.07

Renal disease (creatinine ≥1.5 mg/dL)c

15.4

4.2

(2.1–8.5)

< 0.001

15.9

2.4

(1.6–3.5)

< 0.001

Leukemiab c

None

NA

  

None

NA

  

Lymphomab c

None

NA

  

None

NA

  

Non-metastatic solid tumorb c

2.3

2.4

(0.6–10.1)

0.2

2.1

1.8

(06–5)

0.3

Metastatic solid tumorb c

0.3

NAa

  

0.3

6.8

(5.1–9.1)

< 0.001

AIDSb

0.3

NAa

  

0.3

4.1

(3.3–5.2)

< 0.001

Epilepsyc

3.3

NAa

  

3.5

1.1

(0.6–2.3)

0.7

Substance abuse other than alcoholismv

19.9

1.3

(0.6–2.9)

0.5

19.4

1.5

(1.1–2)

0.018

  1. Abbreviations: AIDS acquired immune deficiency syndrome, CCI Charlson Comorbidity Index (excluding liver disease and liver cancer); HR, CI confidence interval; hazard ratio, LT liver transplant, NA not applicable
  2. aNo patients in the analysis met this endpoint
  3. bScored in the CCI
  4. cScored in the CIRCOM