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Fig. 4 | BMC Gastroenterology

Fig. 4

From: Role of sex hormones and their receptors on gastric Nrf2 and neuronal nitric oxide synthase function in an experimental hyperglycemia model

Fig. 4

Effect of sex hormones and selective ER agonists (ERα; PPT, ERβ; DPN) on nNOS-mediated nitrergic relaxation in an in-vitro hyperglycemia model. (a-d) Neuromuscular strips were stimulated via EFS (2 Hz) after 90-min hyperglycemia incubation. Sex hormones (E2 or P4) or ER-selective agonists (PPT, DPN) were pre-incubated for 90 mins in hyperglycemia prior to second stimulation. L-NAME, nNOS blocker, was used to confirm nitrergic response. Bar graphs showed a ratio (AUC/mg tissue). Data were analyzed using one-way ANOVA by using GraphPad prism software. Data are means ± SEM (n = 4). * p < 0.05 compared with NG groups. # p < 0.05 compared with HG groups

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