The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm

Table 3 Results of univariate and multivariate analyses for factors contributing to the accuracy of PJC for the IPMN diagnosis (n = 90)

			Univariate	Multivariate
Factors	n	Ratio of malignancy, n (%)	P value	Odds ratio	95% CI	P value
Age, ≥ 70 years old	48	26 (54)	0.977
Sex, male	59	27 (46)	0.992
Location of main lesion, Ph	50	23 (46)	0.431
MD or mixed-type, yes	57	31 (54)	0.212
LBC, yes	38	15 (39)	0.044	4.25	1.24–14.54	0.021
SPACE, yes	12	4 (33)	0.142	2.04	0.31–13.28	0.455
Obstructive jaundice, yes	6	6 (100)	0.444
Enhancing MN ≥ 5 mm, yes	31	19 (61)	0.168	0.23	0.07–0.73	0.013
Diameter of MPD ≥ 10 mm, yes	23	14 (61)	0.358
Past history of pancreatitis, yes	10	4 (40)	0.697
Diameter of dilated branch duct ≥3 cm, yes	41	15 (37)	0.043	4.41	1.45–13.35	0.009
Thickness and/or enhancing cyst walls, yes	26	10 (38)	0.276
Abrupt change in caliber of pancreatic duct with distal pancreatic atrophy, yes	22	16 (73)	0.927
Lymphoadenopathy, yes	4	4 (100)	0.092	0.15	0.01–2.12	0.159
Increasing serum level of CA19–9, yes	22	18 (82)	0.002	0.24	0.07–0.79	0.019
Increasing size of cyst over 5 mm/2 years, yes	15	8 (53)	0.617

IPMN, intraductal papillary mucinous neoplasm; CI, confidence interval; Ph, pancreatic head; MD, main duct; LBC, liquid-based cytology; SPACE, serial pancreatic juice aspiration cytological examination; MN, mural nodule; MPD, main pancreatic duct; CA19–9, carbohydrate antigen 19–9

ISSN: 1471-230X