Skip to main content

Table 2 Cox model measured hazard ratios (HRs) and 95% confidence intervals of HCC occurrence associated with and without aspirin use and covariates among HCV carriers

From: Aspirin decreases hepatocellular carcinoma risk in hepatitis C virus carriers: a nationwide cohort study

Characteristics

Event no.

Crude

Adjusted

(n = 278)

HR

(95% CI)

p value

HR

(95% CI)

p value

Aspirin

 No

147

1

reference

 

1

reference

 

 Yes

131

0.73

(0.58–0.93)

0.01

0.56

(0.43–0.72)

< 0.001

Gender

 Female

123

1

reference

 

1

reference

 

 Male

155

1.55

(1.23–1.97)

< 0.001

1.71

(1.35–2.18)

< 0.001

Age, years

  < 40

2

1

reference

 

1

reference

 

 40–59

58

5.83

(1.42–23.87)

0.01

5.42

(1.32–22.25)

0.02

 60–79

192

15.63

(3.88–63.02)

< 0.001

13.45

(3.31–54.59)

< 0.001

  ≥ 80

26

14.79

(3.5–62.56)

< 0.001

12.24

(2.87–52.18)

< 0.001

Baseline comorbidity

 Hypertension

  No

70

1

reference

 

1

reference

 

  Yes

208

1.11

(0.85–1.46)

0.45

1.33

(0.99–1.79)

0.06

 Diabetes mellitus

  No

169

1

reference

 

1

reference

 

  Yes

109

0.84

(0.66–1.06)

0.15

0.81

(0.63–1.05)

0.11

 Moderate or severe liver disease

  No

275

1

reference

 

1

reference

 

  Yes

3

0.77

(0.25–2.39)

0.65

0.83

(0.26–2.59)

0.75

 Myocardial infarction

  No

269

1

reference

 

1

reference

 

  Yes

9

0.53

(0.27–1.03)

0.06

0.59

(0.3–1.15)

0.12

 Congestive heart failure

  No

230

1

reference

 

1

reference

 

  Yes

48

0.84

(0.61–1.15)

0.27

0.87

(0.63–1.2)

0.39

 Ischemic stroke

  No

126

1

reference

 

1

reference

 

  Yes

152

0.86

(0.68–1.09)

0.21

0.83

(0.64–1.07)

0.15

Drugs

 Anti-hypertensive agents

  No

75

1

reference

 

1

reference

 

  Yes

203

1.92

(1.47–2.5)

< 0.001

1.94

(1.45–2.6)

< 0.001

 Hypoglycemic agents

  No

265

1

reference

 

1

reference

 

  Yes

13

0.88

(0.51–1.54)

0.67

0.85

(0.48–1.48)

0.56

 Coumadin and heparin

  No

271

1

reference

 

1

reference

 

  Yes

7

0.61

(0.29–1.28)

0.19

0.52

(0.24–1.11)

0.09

 Other antithrombotic agents

  No

232

1

reference

 

1

reference

 

  Yes

46

1.18

(0.86–1.62)

0.30

1.06

(0.76–1.48)

0.72

 NSAIDs

  No

134

1

reference

 

1

reference

 

  Yes

144

0.83

(0.66–1.05)

0.13

0.83

(0.65–1.05)

0.12

  1. Abbreviations: HR Hazard ratio, CI Confidence interval, NSAIDs Non-steroidal anti-inflammatory drugs
  2. Adjusted HR: adjusted for gender, age, hypertension, diabetes mellitus, moderate or severe liver disease, myocardial infarction, congestive heart failure, ischemic stroke, anti-hypertension agents, hypoglycemic agents, coumadin and heparin, other antithrombotic agents and NSAIDs in Cox proportional hazards regression
Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us