Table 3 Subgroup meta-analysis by region, type of study, diagnostic method and group size for the summarized proportion of NASH patients with normal ALT in overall NASH patients
Variable | Summarized proportion | 95% CI | I2 | P value | Number of studies |
|---|---|---|---|---|---|
Overall estimate | 0.30 | [0.24;0.37] | 85% | < 0.01 | 6 |
Region | |||||
North America | 0.25 | [0.19;0.33] | 85% | < 0.01 | 3 |
Asia | 0.04 | [0.01;0.24] | NA | NA | 1 |
Europe | 0.19 | [0.11;0.30] | 81% | < 0.01 | 2 |
Type of study | |||||
Retrospective cohort study | 0.21 | [0.15;0.29] | 84% | < 0.01 | 5 |
Prospective cohort study | 0.04 | [0.00;0.21] | NA | NA | 1 |
Diagnostic method | |||||
Histology | 0.17 | [0.12;0.25] | 77% | < 0.01 | 5 |
MRI | 0.30 | [0.25;0.37] | NA | NA | 1 |
Group size | |||||
More than 300 | 0.20 | [0.12;0.32] | 91% | < 0.01 | 3 |
300 or less than 300 | 0.20 | [0.15;0.26] | 0% | 0.11 | 3 |