Analysis of the relationship between MIR155HG variants and gastric Cancer susceptibility

BMC Gastroenterology

Table 2 Basic information of candidate single nucleotide polymorphism (SNPs) in the study

SNP ID	Genes	Chr.	Position	Alleles A/B	MAF		p-HWE^a	p^b	OR(95%CI)	HaploReg
SNP ID	Genes	Chr.	Position	Alleles A/B	Case	Control	p-HWE^a	p^b	OR(95%CI)	HaploReg
rs4143370	MIR155HG	chr21	25,564,661	C/G	0.156	0.175	0.087	0.255	0.87 (0.69–1.10)	Promoter histone marks, Enhancer histone marks, DNAse, Proteins bound, Motifs changed, Selected eQTL hits
rs77218221	MIR155HG	chr21	25,565,063	C/T	0.042	0.056	0.662	0.131	0.73 (0.48–1.10)	Promoter histone marks, Enhancer histone marks, Motifs changed
rs77699734	MIR155HG	chr21	25,566,995	C/G	0.096	0.092	0.293	0.778	1.04 (0.77–1.41)	Promoter histone marks, Enhancer histone marks, DNAse, Proteins bound
rs11911469	MIR155HG	chr21	25,567,971	A/C	0.127	0.103	0.339	0.089	1.27 (0.96–1.67)	Promoter histone marks, Enhancer histone marks, DNAse, Proteins bound, Motifs changed
rs1893650	MIR155HG	chr21	25,568,503	C/T	0.189	0.174	0.535	0.391	1.10 (0.88–1.39)	Promoter histone marks, Enhancer histone marks, DNAse, Proteins bound, Motifs changed, GRASP QTL hits, Selected eQTL hits
rs34904192	MIR155HG	chr21	25,569,623	A/G	0.252	0.266	0.423	0.473	0.93 (0.76–1.14)	Promoter histone marks, Enhancer histone marks, DNAse, Proteins bound, Motifs changed, Selected eQTL hits
rs928883	MIR155HG	chr21	25,571,713	A/G	0.435	0.460	0.785	0.256	0.90 (0.76–1.08)	Enhancer histone marks, DNAse, Proteins bound, Motifs changed, Selected eQTL hits

SNP single nucleotide polymorphism, MAF minor allele frequency, HWE Hardy-Weinberg equilibrium, OR odds ratio, 95% CI 95%confidence interval
^a HWE p^a-value were calculated from Fisher’s exact test
^b p values were calculated from two-sided χ² test

ISSN: 1471-230X