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Table 2 Univariate and multivariate logistic regression analysis of factors associated with H. pylori positive and negative

From: Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors

Demographic and clinical data

Total

N = 233

n (%)

H. pylori positive N = 109

n (%)

H. pylori negative N = 124

n (%)

OR crude (95% CI)

P Value

OR adjusted (95% CI)

P value

Gender

 Men

125 (53.6)

55 (44.0)

70 (56.0)

0.78 (0.46–1.31)

0.430

0.51 (0.20–1.33)

0.174

 Women

108 (46.4)

54 (50.0)

54 (50.0)

Ref

 

Ref

 

Age group

 < 35

57 (24.5)

21 (36.8)

36 (63.2)

1.25 (0.80–2.87)

0.196

0.72 (0.20–2.54)

0.612

 35–45

42 (18.0)

25 (59.5)

17 (40.5)

0.60 (0.29–1.21)

0.159

2.47 (0.81–7.53)

0.111

 > 45

134 (57.5)

63 (47.0)

71 (53.0)

Ref

–

Ref

–

BMI

 < 18.5

3 (1.3)

0 (0.0)

3 (100.0)

N/A

–

N/A

–

 18.5–24.9

35 (15.0)

17 (48.6)

18 (51.4)

1.52 (0.57–4.07)

0.398

1.76 (0.44–7.00)

0.420

 25–29.9

145 (62.2)

69 (47.6)

76 (52.4)

1.32 (0.57–3.04)

0.504

1.82 (0.61–5.35)

0.277

 > 30

50 (21.5)

23 (46.0)

27 (54.0)

Ref

–

Ref

-

Number of family member

 < 3

93 (39.9)

37 (39.8)

56 (60.2)

0.62 (0.36–1.06)

0.084

0.74 (0.35–1.56)

0.428

 > 3

140 (60.1)

72 (51.4)

68 (48.6)

Ref

 

Ref

–

Smoking

 Yes

79 (33.9)

33 (41.8)

46 (58.2)

0.73 (0.42–1.27)

0.332

0.68 (0.29–1.62)

0.395

 No

154 (66.1)

76 (49.4)

78 (50.6)

Ref

 

Ref

–

Alcohol drink

 Yes

32 (13.7)

16 (50.0)

16 (50.0)

1.16 (0.55–2.45)

0.707

1.75 (0.60–5.08)

0.301

 No

201 (86.3)

93 (46.3)

108 (53.7)

Ref

 

Ref

–

Education

 Illiterate

10 (4.3)

3 (30.0)

7 (70.0)

0.45 (0.11–1.87)

0.277

0.13 (0.02–0.84)

0.033

 Under diploma

47 (20.2)

24 (51.1)

23 (48.9)

1.11 (0.55–2.24)

0.765

0.43(0.12–1.58)

0.209

 Diploma

83 (35.6)

37 (44.6)

46 (55.4)

0.85 (0.47–1.55)

0.613

0.47 (0.17–1.28)

0.141

Upper graduated

93 (39.9)

45 (48.4)

48 (51.6)

Ref

–

Ref

–

Marital status

 Single

44 (18.9)

12 (27.3)

32 (72.7)

0.35 (0.17–0.73)

0.01

0.38 (0.12–1.13)

0.082

 Married

189 (81.1)

97 (51.1)

92 (48.9)

Ref

 

Ref

–

Occupation

 Unemployed

56 (24.0)

32 (57.1)

24 (42.9)

2.24 (1.08–4.62)

0.029

6.70 (2.22–20.23)

0.001

 Housekeeping

71 (30.5)

32 (45.1)

39 (54.9)

1.37 (0.69–2.72)

0.356

1.03 (0.30–3.49)

0.951

 Employee

39 (16.7)

20 (51.3)

19 (48.7)

1.76 (0.79–3.93)

0.162

0.90 (0.28–2.80)

0.856

 Self employed

67 (28.8)

25 (37.3)

42 (62.7)

Ref

–

Ref

–

Drinking water source

 River

1 (0.4)

1 (100.0)

0 (0.0)

N/A

–

N/A

–

 Tap

153 (65.7)

68 (44.4)

85 (55.6)

0.85 (0.39–1.84)

0.688

0.97 (0.36–2.57)

0.957

 Mineral

48 (20.6)

25 (52.1)

23 (47.9)

1.15 (0.47–2.86)

0.748

1.07 (0.33–3.46)

0.909

 Tap and Mineral

31 (13.3)

15 (48.4)

16 (51.6)

Ref

–

Ref

–

Family history of gastrointestinal cancer

 Yes

44 (18.9)

30 (68.2)

14 (31.8)

2.98 (1.48–5.99)

0.002

3.52 (1.48–8.35)

0.004

 No

189 (81.9)

79 (41.8)

110 (58.2)

Ref

 

Ref

–

Gastrointestinal sign and symptomsa

 Epigastric pain

157 (67.4)

85 (54.1)

72 (45.9)

2.70 (1.50- 4.83)

0.001

4.67 (1.92–11.34)

0.001

 Heartburn

107 (45.9)

24 (31.6)

52 (68.4)

1.06 (0.63–1.78)

0.895

1.83 (0.89–3.75)

0.009

 Reflux

76 (32.6)

34 (44.7)

42 (55.3)

0.88 (0.51–1.53)

0.677

1.35 (0.61–2.99)

0.458

 Weight loss

55 (23.6)

34 (61.8)

21 (38.2)

2.22 (1.19- 4.13)

0.013

3.38 (1.34–8.49)

0.009

 Decreased appetite

64 (27.5)

35 (54.7)

29 (45.3)

1.54 (0.86–2.76)

0.144

1.62 (0.69–3.78)

0.262

 Early satiety

17 (7.3)

8 (47.1)

9 (52.9)

1.01 (0.37–2.72)

0.981

1.73 (0.44–6.77)

0.425

 The presence of blood in the stool

9 (3.9)

2 (22.2)

7 (77.8)

0.31 (0.06–1.55)

0.181

0.66 (0.11–3.88)

0.654

 Iron deficiency anemia

27 (11.6)

15 (55.6)

12 (44.4)

1.48 (0.66–3.33)

0.413

1.62 (0.55–4.79)

0.378

  1. P values less than 0.05 were considered statistically significant
  2. H. pylori Helicobacter pylori, BMI body mass index, OR odd ratio, CI confidence interval
  3. a%s may not add up to 100 as one patient be diagnosed with more than one Gastrointestinal sign and symptoms