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Table 1 Uni- and multivariate analyses of overall survival in patients with resected stage III-IV GBC

From: Examination of the characteristics of long-term survivors among patients with gallbladder cancer with liver metastasis who underwent surgical treatment: a retrospective multicenter study (ACRoS1406)

  

Univariate

Multivariate

n

OS 5 years

p valuea

Hazard ratio (95% CI)

p valueb

Period

07–13′/00–06′

95/98

37.8/21.3

< 0.001

0.63 (0.41–0.95)

0.026

Age (year)

≥ 70/< 70

96/97

33.3/25.7

0.60

  

Sex

Female/male

108/85

27.4/32.1

0.90

  

Preop. Jaundice

Yes/no

63/128

12.1/38.0

< 0.001

1.70 (1.02–2.86)

0.044

NAC

Yes/no

11/182

11.4/30.6

0.30

  

CA19-9, U/L

> 37/≤ 37

110/79

16.2/46.6

< 0.001

1.25 (0.99–1.32)

0.31

CEA, ng/mL

> 5/≤ 5

59/132

15.2/35.6

0.003

1.52 (0.81–1.94)

0.054

Incidental

Yes/no

19/174

9.59/31.3

0.08

  

Hepatectomy

Ch/GB

34/47

34.9/39.5

< 0.001

1.90 (0.95–3.82)

0.071

 

S4aS5/GB

42/47

39.2/39.5

 

1.21 (0.68–2.15)

0.51

 

≥ 3 seg/GB

62/47

11.9/39.5

 

1.71 (0.93–3.13)

0.082

BDR.PD

Absent/BDR

58/107

38.7/24.1

0.06

  
 

PD/ BDR

28/107

30.4/24.1

   

Blood loss, mL

≥ 864/< 864

91/90

13.5/42.0

< 0.001

1.33 (0.79–2.23)

0.29

Surgery time, min

≥ 366/< 366

91/90

18.2/37.9

0.001

1.08 (0.66–1.79)

0.76

Histology

pap/tub1.2

23/129

50.2/27.0

0.02

0.59 (0.29–1.20)

0.15

 

tub3/tub1.2

40/129

23.7/27.0

 

1.42 (0.84–2.38)

0.19

AJCC T 8th

T2/T3

50/102

43.6/27.4

< 0.001

1.30 (0.74–2.27)

0.36

 

T4/T3

41/102

16.5/27.4

 

1.12 (0.65–1.95)

0.67

AJCC N 8th

N0/N1

65/77

39.2/26.1

0.07

  
 

N2/N1

14/77

9.23/26.1

   
 

Distant/N1

37/77

25.0/26.1

   

H

H1/H0

12/167

30.1/46.3

0.03

1.03 (0.43–2.49)

0.94

 

H2/H0

14/167

7.69/46.3

 

2.11 (1.06–4.21)

0.035

P

P1.2/P0

16/177

0/32.2

< 0.001

2.08 (1.05–4.12)

0.036

Residual cancer

R1.2/R0

60/131

12.1/36.9

< 0.001

1.29 (0.82–2.02)

0.27

Morbidity*

≥ 3/≤ 2

54/137

18.6/33.8

0.004

1.44 (0.94–2.22)

0.097

AC

with /without

86/98

32.8/28.5

0.30

  
  1. Bold values indicate p < 0.05
  2. OS, overall survival; NAC, Neoadjuvant chemotherapy; CA, cancer antigen; CEA, carcinoembryonic antigen; CI, confidence interval; GB, gallbladder bed resection; Ch, cholecystectomy; S4aS5, resection of segment 4a plus 5 of the liver; BDR, bile duct resection; PD, pancreatoduodenectomy; AJCC, American Joint Committee on Cancer
  3. *Clavien–Dindo classification; AC, adjuvant chemotherapy. pap/tub1/tub2/tub3/other, T2/T3/T4, N0/N1/N2/Distant LNM, H0/H1/H2, P0/P1/P2, R0 (see Additional file 1: Table S1)
  4. aLog-rank test
  5. bCox proportional hazards model
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BMC Gastroenterology

ISSN: 1471-230X

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