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Fig. 1 | BMC Gastroenterology

Fig. 1

From: The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways

Fig. 1

Downregulation of STAG3 expression is frequently observed and associated with poor prognosis in HCC patients. A IHC analysis of STAG3 expression in 126 HCC tissue samples and 28 paracarcinoma tissue samples. Representative images are shown (Scale bar, 50 μm, upper picture; scale bar, 15 μm, lower picture). B RT–qPCR analysis of the relative mRNA levels of STAG3 in 6 pairs of HCC tumor (T) and nontumor tissues (N). C RT–qPCR analysis of STAG3 mRNA expression in HCC cells compared with normal hepatic cells. D Patients with low expression levels of STAG3 had a shorter OS than patients with high expression levels of STAG3, as determined using datasets from TCGA. E OS analysis of HCC patients based on STAG3 expression in 126 samples. *P < 0.05; **P < 0.01; ***P < 0.001

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BMC Gastroenterology

ISSN: 1471-230X

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