The impact of serum thyroid-stimulation hormone levels on the outcome of hepatitis B virus related acute-on-chronic liver failure: an observational study

Table 2 Multivariate Cox proportional hazards regression analysis

Variable	30 days survival			90 days survival
Variable	HR	95%CI	P	HR	95%CI	P
Age,y	1.026	1.019–1.034	< 0.001	1.029	1.023–1.035	< 0.001
WBC (× 10⁹/L)	1.035	1.017–1.054	< 0.001	1.029	1.013–1.046	< 0.001
AST (U/L)	1.000	1.000–1.001	< 0.001	1.000	1.000–1.001	< 0.001
ALB (g/L)	0.969	0.949–0.990	0.003	–	–	–
TBil (µmol/L)	1.002	1.001–1.002	< 0.001	1.002	1.001–1.002	< 0.001
INR	1.064	1.046–1.082	< 0.001	1.060	1.045–1.076	< 0.001
Cr (µmol/L)	1.003	1.001–1.004	< 0.001	1.002	1.001–1.004	< 0.001
AFP (ng/mL)	0.998	0.997–0.999	< 0.001	0.999	0.998–0.999	< 0.001
HBV DNA (IU/mL, > 156,000 vs. < 156,000)	1.550	1.275–1.884	< 0.001	1.498	1.279–1.755	< 0.001
TSH(µIU/mL)	0.743	0.629–0.878	< 0.001	0.807	0.717–0.909	< 0.001
Pre-existing chronic liver diseases (Cirrhosis vs. Chronic hepatitis)	1.287	1.047–1.582	0.017	1.557	1.296–1.871	< 0.001
Hepatorenal Syndrome (Yes vs. No)	1.510	1.054–2.164	0.025	–	–	–
Hepatic Encephalopathy (Grade 3 vs. Grade 1–2 vs. None)	2.630	2.258–3.064	< 0.001	2.140	1.873–2.445	< 0.001
Gastrointestinal Bleeding (Yes vs. No)	–	–	–	1.636	1.052–2.543	0.029
Infection (Yes vs. No)	–	–	–	1.259	1.052–1.506	0.012

AFP alpha fetal protein; ALB albumin; AST glutamic-oxaloacetic transaminase; CI confidence interval; Cr serum creatinine; HBV hepatitis B virus; HR hazard ratio; INR international normalized ratio; TBil total bilirubin; TSH thyroid-stimulation hormone; WBC white blood cell

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