Table 3 Self-report of adverse events 2

Nausea

Tolerable

1

If I use anti-nausea drugs, I can manage to eat

2

I can hardly eat because of nausea

3

Anorexia

I have a slight loss of appetite

1

I can eat somehow

2

I can hardly eat

3

Malaise

I am a little tired, but it does not interfere with my daily life

1

I often lie down

2

I lie down more often than I am awake

3

Bedridden all day long

4

Diarrhea

Increased defecation frequency less than 4 times a day compared to usual

1

Increased defecation frequency 4–6 times a day compared to usual

2

Increased defecation frequency more than 7 times a day compared to usual

3

If you have any other symptoms of concern, please write them down