Total neoadjuvant therapy for locally advanced gastric cancer and esophagogastric junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase II clinical trial

Table 3 Assessment and intervention schedule for the trial

	Screening	During NCRT	Before NCT	During NCT	Before surgery	Follow-up
	Screening	During NCRT	Before NCT	During NCT	Before surgery	Year 1-2: every 3 months	Year 3-5: every 6 months	> 5 year: every 1 year
Physical examination	√	X	√	X	√	√	√	√
Blood routine	√	X	√	X	√	√	√	√
Urine routine	√				√
Stool routine	√				√
Biochemical test	√	△	√	△	√	√	√	√
CEA	√		√	○	√	√	√	√
CA199	√		√	○	√	√	√	√
CA724	√		√	○	√	√	√	√
Electrocardiogram	√				√
Enhanced CT*	√		√	○	√	√	√	√
Ultrasound**	√		√	○	√	√	√	√
Gastroscopy	√				√	√	√	√
Endoscopic ultrasound	√				√
Pathology	√

ISSN: 1471-230X