Skip to main content

Table 2 Univariate and multivariate analysis of clinicopathologic variables in relation to PFS in patients living with HIV for GC

From: Preoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center study

Clinicopathological features

Univariate analysis

 

Multivariate analysis

 

HR (95% CI)

P value

HR (95% CI)

P value

Gender

 Female

Reference

   

 Male

0(0-Inf)

0.998

  

Age

0.961(0.904–1.02)

0.192

  

BMI

0.763(0.641–0.909)

0.002

0.884(0.684–1.142)

0.346

Hypertension

 Yes

0.363(0.084–1.572)

0.176

  

DM

 Yes

1.282(0.428–3.839)

0.657

  

TB

 Yes

0.824(0.109–6.21)

0.851

  

Smoking

 Yes

0.177(0.024–1.325)

0.092

  

Alcohol abuse

 Yes

0.399(0.053–2.991)

0.371

  

Hyperlipidemia

 Yes

0.805(0.235–2.753)

0.729

  

Duration of HIV infection

1.003(0.992–1.015)

0.586

  

Duration of HIV treatment

1.003(0.991–1.016)

0.58

  

Tumor Location

 Upper

Reference

   

 Middle

0.635(0.208–1.935)

0.424

  

 Lower

1.14(0.208–6.247)

0.88

  

Histology

 Signet ring cell

3.939(1.578–9.836)

0.003

42.638(6.245–291.092)

 < 0.001

R0 rescetion

 No

4.245(1.382–13.038)

0.012

136.565(8.048–2317.405)

 < 0.001

Her2 status

 0

Reference

   

 1 + 

0.806(0.302–2.149)

0.667

  

 2 + 

0.563(0.126–2.521)

0.453

  

AJCC stage

 I-II

Reference

 

Reference

 

 III-IV

6.297(1.96–20.228)

0.002

0.766(0.135–4.341)

0.764

ALB (g/L)

 > 38.1

Reference

 

Reference

 

 ≤ 38.1

4.041(1.553–10.515)

0.004

3.73(0.309–45.103)

0.301

CD8 count (per ul)

 > 661

Reference

   

 ≤ 661

0.741(0.302–1.822)

0.514

  

CD4 count (per ul)

 > 348

Reference

   

 ≤ 348

2.667(0.957–7.436)

0.061

  

CD4/CD8

 > 0.71

Reference

   

 ≤ 0.71

1.52(0.581–3.978)

0.394

  

NLR

 > 3.9

Reference

 

Reference

 

 ≤ 3.9

0.346(0.137–0.873)

0.025

0.109(0.008–1.56)

0.103

LMR

 > 6.5

Reference

   

 ≤ 6.5

3.538(0.472–26.497)

0.219

  

PLR

 > 199.0

Reference

 

Reference

 

 ≤ 199.0

0.298(0.123–0.723)

0.007

0.027(0.004–0.201)

 < 0.001

PNI

 > 43.4

Reference

 

Reference

 

 ≤ 43.4

3.129(1.265–7.737)

0.014

0.756(0.057–10.062)

0.832

SII

 > 935

Reference

 

Reference

 

 ≤ 935

0.275(0.104–0.729)

0.009

14.322(0.783–261.811)

0.073

SIS

 0

Reference

   

 1

0.555(0.156–1.978)

0.364

  

 2

1.667(0.515–5.393)

0.393

  
  1. DM diabetes mellitus, TB tuberculosis infection status, Her2 status immunohistochemical staining of Her-2, ALB serum albumin, NLR neutrophil–lymphocyte ratio, LMR lymphocyte-monocyte ratio, PLR platelet-lymphocyte ratio, PNI prognostic nutritional index, SII systemic immune-inflammation index, SIS systemic inflammation score