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Gastroesophageal disorders

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of severe weight loss posto...

    Authors: Yasufumi Koterazawa, Taro Oshikiri, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki and Yoshihiro Kakeji

    Citation: BMC Gastroenterology 2020 20:407

    Content type: Research article

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  2. The resistance rate of Helicobacter pylori to clarithromycin (CAM) is high among infected children in Japan. Therefore, a new method for detecting CAM-resistant H. pylori using a minimally invasive technique is s...

    Authors: Toshihiko Kakiuchi, Kazutoshi Hashiguchi, Ichiro Imamura, Aiko Nakayama, Ayako Takamori, Masumi Okuda and Muneaki Matsuo

    Citation: BMC Gastroenterology 2020 20:397

    Content type: Technical advance

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  3. There are often specific endoscopic findings caused by deposition of lanthanum (La) in the gastric mucosa of patients taking lanthanum carbonate (LaC), a novel phosphate binder for patients on hemodialysis. We...

    Authors: Shinya Nishida, Kazuhiro Ota, Kimiaki Hattori, Taro Iwatsubo, Shimpei Kawaguchi, Yuichi Kojima, Toshihisa Takeuchi, Tamaki Maeda, Masahiro Sakaguchi and Kazuhide Higuchi

    Citation: BMC Gastroenterology 2020 20:396

    Content type: Research article

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  4. The current virtual chromoendoscopy equipment cannot completely detect superficial squamous cell carcinoma (SCC) in the esophagus, despite its development in the recent years. Thus, in this study, we aimed to ...

    Authors: Taro Iwatsubo, Ryu Ishihara, Yasushi Yamasaki, Yusuke Tonai, Kenta Hamada, Minoru Kato, Sho Suzuki, Mitsuhiro Kono, Hiromu Fukuda, Yusaku Shimamoto, Kentaro Nakagawa, Masayasu Ohmori, Masamichi Arao, Kenshi Matsuno, Hiroyoshi Iwagami, Shuntaro Inoue…

    Citation: BMC Gastroenterology 2020 20:389

    Content type: Research article

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  5. Amplification of HER2 gene (ERBB2) and overexpression of HER2 protein on cancer cells are found in 10–26% of gastric cancer (GC) and esophagogastric junction cancer (EGJC). Gene copy number variation (CNV) could ...

    Authors: Anna Grenda, Kamila Wojas-Krawczyk, Tomasz Skoczylas, Paweł Krawczyk, Jadwiga Sierocińska-Sawa, Grzegorz Wallner and Janusz Milanowski

    Citation: BMC Gastroenterology 2020 20:382

    Content type: Research article

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  6. To develop the Patient Health Questionnaire-8 (PHQ-8) as a more reliable approach than the Somatic Symptom Scale-8 (SSS-8), evaluating somatization which might be a critical factor influencing the quality of l...

    Authors: Chaoqun Yuan, Guizhen Yong, Xi Wang, Ting Xie, Chunyan Wang, Yuan Yuan and Guobin He

    Citation: BMC Gastroenterology 2020 20:359

    Content type: Research article

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  7. With more prevalent gastroesophageal reflux disease comes increased cases of Barrett's esophagus and esophageal adenocarcinoma. Image-enhanced endoscopy using linked-color imaging (LCI) differentiates between ...

    Authors: Tsutomu Takeda, Daisuke Asaoka, Daiki Abe, Maiko Suzuki, Yuta Nakagawa, Hitoshi Sasaki, Yoshihiro Inami, Muneo Ikemura, Hisanori Utsunomiya, Shotaro Oki, Nobuyuki Suzuki, Atsushi Ikeda, Noboru Yatagai, Hiroyuki Komori, Yoichi Akazawa, Kohei Matsumoto…

    Citation: BMC Gastroenterology 2020 20:356

    Content type: Research article

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  8. Placement of feeding jejunostomy (PFJ) during esophagectomy is an effective method to maintain adequate nutrition, but is associated with serious complications such as bowel obstruction and jejunal torsion. Th...

    Authors: Teppei Kamada, Hironori Ohdaira, Hideyuki Takeuchi, Junji Takahashi, Rui Marukuchi, Eisaku Ito, Norihiko Suzuki, Satoshi Narihiro, Sojun Hoshimoto, Masashi Yoshida, Mitsuyoshi Urashima and Yutaka Suzuki

    Citation: BMC Gastroenterology 2020 20:354

    Content type: Research article

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  9. Early gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. At present, differences in clinicopathology remai...

    Authors: Yaohui Wang, Xiuqing Li, Lili Gao, Chenxi Wang, Yifen Zhang and Qin Huang

    Citation: BMC Gastroenterology 2020 20:351

    Content type: Research article

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  10. The significance of human epidermal growth factor receptor 2 (Her2) and nucleus-associated antigen Ki-67 expression remains controversial in gastric adenocarcinoma (GaC). The aim of this study was to investiga...

    Authors: Zhijian Wei, Lei Huang, Xinyue Zhang and Aman Xu

    Citation: BMC Gastroenterology 2020 20:343

    Content type: Research article

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  11. Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract is a rare low-grade clonal lymphoid proliferation, included as a provisional entity in the current World Health Organization classific...

    Authors: Magda Zanelli, Maurizio Zizzo, Francesca Sanguedolce, Giovanni Martino, Alessandra Soriano, Stefano Ricci, Carolina Castro Ruiz, Valerio Annessi and Stefano Ascani

    Citation: BMC Gastroenterology 2020 20:336

    Content type: Case report

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  12. Anastomotic leakage is common and life-threatening complication after esophagectomy. The management of esophageal anastomotic leakage remains challenging. We aimed to determine the safety, feasibility and effi...

    Authors: Yonghua Bi, Zhengyang Wu, Mengfei Yi, Xinwei Han and Jianzhuang Ren

    Citation: BMC Gastroenterology 2020 20:330

    Content type: Research article

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  13. Postoperative pancreatic fistula (POPF) is a serious complication after gastric cancer surgery. The current study aimed to investigate the significance of the anatomic location of the pancreas as a predictor f...

    Authors: Jun Kinoshita, Takahisa Yamaguchi, Hiroto Saito, Hideki Moriyama, Mari Shimada, Shiro Terai, Koichi Okamoto, Shinichi Nakanuma, Isamu Makino, Keishi Nakamura, Hidehiro Tajima, Itasu Ninomiya and Sachio Fushida

    Citation: BMC Gastroenterology 2020 20:325

    Content type: Research article

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  14. Gastroparesis, a condition of abnormal gastric emptying, is most commonly observed in diabetic women. To date, the role of ovarian hormones and/or gastric hormone receptors on regulating nitrergic-mediated gas...

    Authors: Jeremy Sprouse, Chethan Sampath and Pandu R. Gangula

    Citation: BMC Gastroenterology 2020 20:313

    Content type: Research article

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  15. Changes in the esophageal microbiome correlate with esophageal disease, but the effects of proton pump inhibitor (PPI) drugs are incompletely characterized. Our objective was to identify the effects of PPI use...

    Authors: Sadia Tasnim, Aaron L. Miller, Daniel C. Jupiter, Catherine F. Hamilton, Gabriel L. Reep, Timothy S. Krill, Richard B. Pyles and Ikenna C. Okereke

    Citation: BMC Gastroenterology 2020 20:312

    Content type: Research article

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  16. Delayed post-polypectomy bleeding (PPB) is a major complication of polypectomy. The effect of prophylactic hemoclipping on delayed PPB is uncertain. The aim of this study was to evaluate the effectiveness of p...

    Authors: Chun-Wei Chen, Chia-Jung Kuo, Cheng-Tang Chiu, Ming-Yao Su, Chun-Jung Lin, Puo-Hsien Le, Siew-Na Lim, Chau-Ting Yeh, Malcolm R. Alison and Wey-Ran Lin

    Citation: BMC Gastroenterology 2020 20:309

    Content type: Research article

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  17. Edwardsiella tarda is a motile, facultatively anaerobic gram-negative bacillus that is isolated from a wide spectrum of animals in aquatic environments but rarely causes infection in humans. Here, we describe the...

    Authors: Koshi Ota, Hiroki Yamanoue, Nobuyuki Aizawa, Naoyuki Suzuki, Kanna Ota and Akira Takasu

    Citation: BMC Gastroenterology 2020 20:299

    Content type: Case report

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  18. It is unclear if the 99mTc-sodium phytate (99mTc-SP) is as reliable as the gold-standard 99mTc-sulfur colloid (99mTc-SC) for gastric emptying scintigraphy (GES). This study is aimed to compare the emptying rates ...

    Authors: Norazlina Mat Nawi, Nashrulhaq Tagiling, Mohd Fazrin Mohd Rohani, Wan Mohd Nazlee Wan Zainon, Muhammad Saifuddin Zanial, Mung Seong Wong and Yeong Yeh Lee

    Citation: BMC Gastroenterology 2020 20:293

    Content type: Research article

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  19. With the recent increased use of lanthanum carbonate, several cases of lanthanum phosphate deposition to gastric mucosa in dialysis patients have been reported. However, the endoscopic appearance of the early-...

    Authors: Akiko Ohno, Jun Miyoshi, Hidesato Tanabe, Mitsunori Kusuhara, Masao Toki, Tomohiro Chiba, Hiroaki Shimoyamada, Junji Shibahara and Tadakazu Hisamatsu

    Citation: BMC Gastroenterology 2020 20:292

    Content type: Case report

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  20. Esophageal tuberculosis (ET) is relatively rare, and the diagnosis is challenging. The aim of this study was to evaluate the clinical features of ET and highlight the role of endoscopic ultrasonography (EUS) i...

    Authors: Rong Zhu, Yonghua Bai, Yuankun Zhou, Xingguo Fang, Kui Zhao, Biguang Tuo and Huichao Wu

    Citation: BMC Gastroenterology 2020 20:291

    Content type: Research article

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  21. The extraesophageal manifestations of gastroesophageal reflux disease (GERD) are more difficult to manage than the typical symptoms. The efficacy of high-dose and standard-dose proton pump inhibitors against t...

    Authors: Jae Ho Cho, Cheol Min Shin, Hyuk Yoon, Young Soo Park, Nayoung Kim and Dong Ho Lee

    Citation: BMC Gastroenterology 2020 20:275

    Content type: Research article

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  22. Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of early gastric carcinomas. Clinicopathological features of this variant remain obscure, especially in C...

    Authors: Yuqing Cheng, Xiaoli Zhou, Kequn Xu, Jin Huang and Qin Huang

    Citation: BMC Gastroenterology 2020 20:273

    Content type: Research article

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  23. Approximately 15% of all cancers are due to infection. The bacteria Helicobacter pylori is the single leading carcinogenic infectious agent and the main cause of stomach cancer. Prevalence of H. pylori, and, corr...

    Authors: Sydnee Crankshaw, Julia Butt, Jennifer M. Gierisch, Nadine J. Barrett, Sabrena Mervin-Blake, Kevin Oeffinger, Steven Patierno, Valarie Worthy, Ronald Godbee and Meira Epplein

    Citation: BMC Gastroenterology 2020 20:261

    Content type: Research article

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  24. Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. Therefore, identifying the predictive factors for surgical morbidity, disease recurrence, and long-term survival is necessa...

    Authors: Hitomi Takechi, Nobuaki Fujikuni, Kazuaki Tanabe, Minoru Hattori, Hironobu Amano, Toshio Noriyuki and Masahiro Nakahara

    Citation: BMC Gastroenterology 2020 20:256

    Content type: Research article

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  25. Controversies in terms of efficacy and postoperative advantages surround stapled esophagogastric anastomosis compared with the hand-sewn technique as a treatment for patients with esophageal cancer. The purpos...

    Authors: Seyed Ziaeddin Rasihashemi, Ali Ramouz, Samad Beheshtirouy and Hassan Amini

    Citation: BMC Gastroenterology 2020 20:250

    Content type: Research article

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  26. Esophageal fistula and stricture is rare but life-threatening complication for esophageal cancer. The management of esophageal fistula and stricture remains challenging. We aimed to determine the safety, feasi...

    Authors: Yonghua Bi, Mengfei Yi, Zepeng Yu, Xinwei Han and Jianzhuang Ren

    Citation: BMC Gastroenterology 2020 20:248

    Content type: Research article

    Published on:

  27. NETest, a novel multi-gene liquid biopsy has utility in neuroendocrine tumor (NET) diagnosis and identification of residual disease. We independently assessed utility of the NETest to diagnose gastric neuroend...

    Authors: A. Malczewska, A. Procner, A. Walter, K. Kusnierz, W. Zajecki, H. Aslanian and B. Kos-Kudla

    Citation: BMC Gastroenterology 2020 20:235

    Content type: Research article

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  28. Melatonin has been shown with anticancer property and therapeutic potential for tumors. However, there lacks a systematic study on the molecular pathways of melatonin and its antitumor effects in gastrointesti...

    Authors: Lu Ao, Li Li, Huaqin Sun, Huxing Chen, Yawei Li, Haiyan Huang, Xianlong Wang, Zheng Guo and Ruixiang Zhou

    Citation: BMC Gastroenterology 2020 20:233

    Content type: Research article

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  29. Gastric cancer after Helicobacter pylori (HP) eradication is a crucial clinical challenge today as HP eradication therapy is widely performed. Detecting gastric cancer after HP eradication tends to be difficult w...

    Authors: Akiko Ohno, Jun Miyoshi, Atsushi Kato, Naohiko Miyamoto, Takahito Yatagai, Yu Hada, Mitsunori Kusuhara, Yoko Jimbo, Yosuke Ida, Kengo Tokunaga, Susumu Okamoto and Tadakazu Hisamatsu

    Citation: BMC Gastroenterology 2020 20:232

    Content type: Research article

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  30. There is no current standard rescue treatment for dual drug-resistant strains of Helicobacter pylori (H. pylori). This aim of this study was to investigate the efficacy of rifabutin-based triple therapy for patie...

    Authors: Chia-Jung Kuo, Cheng-Yu Lin, Puo-Hsien Le, Pi-Yueh Chang, Chih-Ho Lai, Wey-Ran Lin, Ming-Ling Chang, Jun-Te Hsu, Hao-Tsai Cheng, Chi-Nan Tseng, Chun-Jung Lin, Ming-Yao Su, Sen-Yung Hsieh and Cheng-Tang Chiu

    Citation: BMC Gastroenterology 2020 20:218

    Content type: Research article

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  31. Gastroparesis is a recognized complication of diabetes but its pathogenic mechanism incompletely understood. Our aim was to determine whether HIF-1α and VEGF are secreted from gastric tissue is a fundamental f...

    Authors: Xueping Wu, Zhifang Yang, Zhihong Li, Ling Yang, Xinyan Wang, Congrong Wang and Jun Gu

    Citation: BMC Gastroenterology 2020 20:216

    Content type: Research article

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  32. Periampullary adenocarcinoma is a major clinical problem in high-risk patients including FAP population. A recent modification for visualizing the ampulla of Vater (AV) involves attaching a cap to the tip of t...

    Authors: Leonardo Correa Silva, Rondinelle Martins Arruda, Paula Fortuci Resende Botelho, Leonardo Nogueira Taveira, Kelly Menezio Giardina, Marco Antonio de Oliveira, Julia Dias, Cleyton Zanardo Oliveira, Gilberto Fava and Denise Peixoto Guimarães

    Citation: BMC Gastroenterology 2020 20:214

    Content type: Research article

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  33. Although endoscopic resection is safe and effective for gastric epithelial neoplasms, information is limited on its efficacy and safety in extremely elderly patients who have various comorbidities. Further, th...

    Authors: Sunmin Kim, Dong Hyun Kim, Seon-Young Park, Chang Hwan Park, Hyun Soo Kim, Sung Kyu Choi and Jong Sun Rew

    Citation: BMC Gastroenterology 2020 20:213

    Content type: Research article

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  34. Recurrence risk is a major concern after endoscopic resection (ER) of gastric neoplasms. This study was to compare metachronous risk in patients with and without synchronous neoplasms after complete ER.

    Authors: Ga-Yeong Shin, Hye Jin Cho, Jae Myung Park, Chul-Hyun Lim, Yu Kyung Cho and Myung-Gyu Choi

    Citation: BMC Gastroenterology 2020 20:206

    Content type: Research article

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  35. Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the le...

    Authors: Khalid Al-Regaiey, Suad Alshubrami, Ibrahim Al-Beeshi, Torki Alnasser, Abdulnasser Alwabel, Hassan Al-Beladi, Omar Al-Tujjar, Abdulrahman Alnasser, Assim A. Alfadda and Muhammad Iqbal

    Citation: BMC Gastroenterology 2020 20:199

    Content type: Research article

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  36. Placement of nasogastric (NG) tubes is a common procedure for patients especially in intensive care units (ICUs). Thus, it is important to determine the correct placement of the tube to prevent misplacement in...

    Authors: Elahe Heidarzadi, Rostam Jalali, Behzad Hemmatpoor and Nader Salari

    Citation: BMC Gastroenterology 2020 20:196

    Content type: Research article

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  37. Recently, a new international bleeding score was developed to predict 30-day hospital mortality in patients with upper gastrointestinal bleeding (UGIB). However, the efficacy of this newly developed scoring sy...

    Authors: Min Seong Kim, Hee Seok Moon, In Sun Kwon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Jae Kyu Sung, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee and Hyun Yong Jeong

    Citation: BMC Gastroenterology 2020 20:193

    Content type: Research article

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  38. The prevalence of Eosinophilic esophagitis (EoE) is increasing, a severe complication of EoE is spontaneous perforation of the oesophagus. It is of great importance to be aware of this risk and handle this sev...

    Authors: Helen Larsson and Stephen Attwood

    Citation: BMC Gastroenterology 2020 20:185

    Content type: Case report

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  39. Cyanoacrylate alone or in combination with other interventions, can be used to achieve variable rates of success in preventing rebleeding. Our study aims to assess the pooled risk of gastric and esophageal var...

    Authors: Zixuan Hu, Decai Zhang, Joel Swai, Tao Liu and Shaojun Liu

    Citation: BMC Gastroenterology 2020 20:181

    Content type: Research article

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  40. The prevalence of Barrett’s esophageal adenocarcinoma (BEA) is increasing in Japan. Accurate assessment of lymphovascular invasion (LVI) after endoscopic resection or surgery is essential in evaluating treatme...

    Authors: Isao Hosono, Ryoji Miyahara, Kazuhiro Furukawa, Kohei Funasaka, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Takio Yokoi, Tetsuya Tsukamoto, Yoshiki Hirooka and Mitsuhiro Fujishiro

    Citation: BMC Gastroenterology 2020 20:175

    Content type: Research article

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  41. Outcomes of gastroesophageal reflux disease (GERD) using Toupet fundoplication (TF) and Stretta radiofrequency (SRF) have not been compared and this study was conducted to compare therapeutic efficacy of the t...

    Authors: Lifeng Ma, Tao Li, Guochao Liu, Jianlong Wang, Zhaoqiang Yin and Jiansheng Kang

    Citation: BMC Gastroenterology 2020 20:162

    Content type: Research article

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  42. The reflux of noxious contents of the stomach may cause oesophageal and extra-oesophageal complications either by direct contact of aspirated gastric refluxate with the upper airway or by a vago-vagal reflex. ...

    Authors: Moses Ayodele Akinola, Titus Ayodeji Oyedele, Kolawole Oluseyi Akande, Olukayode Yinka Oluyemi, Omotayo Felicia Salami, Alaba Moses Adesina and Adedeji David Adebajo

    Citation: BMC Gastroenterology 2020 20:160

    Content type: Research article

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  43. Gastric cancer (GC) is a malignant tumour originating from the gastric mucosa epithelium that seriously threatens human health. DCLK1, miR-15b and lncRNA SNHG1 play potential roles in the occurrence of GC, but...

    Authors: Zhi-Qi Liu, Wei-Feng He, Yang-Jie Wu, Shun-Li Zhao, Ling Wang, Yan-Yi Ouyang and San-Yuan Tang

    Citation: BMC Gastroenterology 2020 20:156

    Content type: Research article

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  44. Many studies have found that large tumor suppressor kinase 1 (LATS1) and LATS2 play important roles in many diseases, but studies have been rare on the relationship between these genes and non-cardia gastric c...

    Authors: Li-cong Ma, Xu-yang Tian, Fang Gao, Wen-jie Dong, Tong Dang and Yan-bin Jia

    Citation: BMC Gastroenterology 2020 20:155

    Content type: Research article

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  45. Oesophageal stents have several well-known respiratory complications, including aspiration pneumonia, fistula and airway compression. However, bilateral vocal cord paralysis has rarely been described.

    Authors: Y. Chiche, G. Beltramo, T. Degand, A. Drouillard, C. Foignot, N. Baudouin, P. Bonniaud and M. Georges

    Citation: BMC Gastroenterology 2020 20:153

    Content type: Case report

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  46. Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteri...

    Authors: Javad Behroozi, Shirin Shahbazi, Mohammad Reza Bakhtiarizadeh and Habibollah Mahmoodzadeh

    Citation: BMC Gastroenterology 2020 20:152

    Content type: Research article

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