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  1. Intestinal microbiota operated as a whole and was closely related with human health. Previous studies had suggested close relationship between liver cirrhosis (LC) and gut microbiota.

    Authors: Xiao Wei, Shan Jiang, Yuye Chen, Xiangna Zhao, Huan Li, Weishi Lin, Boxing Li, Xuesong Wang, Jing Yuan and Yansong Sun
    Citation: BMC Gastroenterology 2016 16:121
  2. Ulcerative colitis (UC) is a chronic inflammatory disorder of still unknown pathogenesis. Increasing evidence indicates that alterations in mitochondrial respiration and thus adenosine triphosphate (ATP) produ...

    Authors: Theresa Dankowski, Torsten Schröder, Steffen Möller, Xinhua Yu, David Ellinghaus, Florian Bär, Klaus Fellermann, Hendrik Lehnert, Stefan Schreiber, Andre Franke, Christian Sina, Saleh M. Ibrahim and Inke R. König
    Citation: BMC Gastroenterology 2016 16:118
  3. While mortality in the United States has decreased for most cancers, mortality from combined hepatocellular liver cancer and intrahepatic cholangiocarcinoma (ICC) has increased and ranked 1st in annual percent...

    Authors: Kaelan J. Yao, Salma Jabbour, Niyati Parekh, Yong Lin and Rebecca A. Moss
    Citation: BMC Gastroenterology 2016 16:117
  4. Authors: Kimitoshi Kubo, Hiroshi Kawakami, Masaki Kuwatani, Mutsumi Nishida, Kazumichi Kawakubo, Shuhei Kawahata, Yoko Taya, Yoshimasa Kubota, Toraji Amano, Hiroki Shirato and Naoya Sakamoto
    Citation: BMC Gastroenterology 2016 16:116

    The original article was published in BMC Gastroenterology 2016 16:65

  5. International guidelines recommend coeliac serology in iron deficiency anaemia, and duodenal biopsy for those tested positive to detect coeliac disease. However, pre-endoscopy serology is often unavailable, th...

    Authors: Michelle Shui Yee Lau, Peter D. Mooney, William L. White, Victoria Appleby, Sulleman Moreea, Ismail Haythem, Joshua E. Elias, Kiran Bundhoo, Gareth D. Corbett, Liam Wong, Her Hsin Tsai, Simon S. Cross, John M. Hebden, Sami Hoque and David S. Sanders
    Citation: BMC Gastroenterology 2016 16:115

    The Erratum to this article has been published in BMC Gastroenterology 2016 16:122

  6. Cirrhosis patients are prescribed multiple medications for their liver disease and comorbidities. Discrepancies between medicines consumed by patients and those documented in the medical record may contribute ...

    Authors: Kelly L. Hayward, Patricia C. Valery, W. Neil Cottrell, Katharine M. Irvine, Leigh U. Horsfall, Caroline J. Tallis, Veronique S. Chachay, Brittany J Ruffin, Jennifer H. Martin and Elizabeth E. Powell
    Citation: BMC Gastroenterology 2016 16:114
  7. To assess public preferences for colorectal cancer (CRC) surveillance tests for intermediate-risk adenomas, using a hypothetical scenario.

    Authors: Bernardette Bonello, Alex Ghanouni, Harriet L. Bowyer, Eilidh MacRae, Wendy Atkin, Stephen P. Halloran, Jane Wardle and Christian von Wagner
    Citation: BMC Gastroenterology 2016 16:113
  8. We developed a novel artificial simulator for endoscopic submucosal dissection (ESD) as a bridge between instructional videos and animal tissue training and aimed to evaluate the feasibility of using an artifi...

    Authors: Ming-Jen Chen, Horng-Yuan Wang, Chen-Wang Chang, Ching-Chung Lin, Chih-Jen Chen, Cheng-Hsin Chu, Tsang-En Wang and Shou-Chuan Shih
    Citation: BMC Gastroenterology 2016 16:112
  9. Gastric neuroendocrine neoplasms (G-NENs) are uncommon, and data on their management is limited. We here investigated the clinicopathological characteristics, surgical and survival outcomes in G-NENs among Chi...

    Authors: Chaoyong Shen, Huijiao Chen, Haining Chen, Yuan Yin, Luyin Han, Jiaju Chen, Sumin Tang, Xiaonan Yin, Zongguang Zhou, Bo Zhang and Zhixin Chen
    Citation: BMC Gastroenterology 2016 16:111
  10. Gastric cancer is the fourth most common cancer worldwide and more frequently detected in Asian countries including Korea and Japan. The incidence of young-age gastric cancer (GC) is increasing worldwide, but ...

    Authors: Jieun Lee, Myung Ah Lee, In-Ho Kim and Sang-Young Roh
    Citation: BMC Gastroenterology 2016 16:110
  11. Gastric intestinal metaplasia (IM) is generally considered as a precancerous condition, a related risk factor for intestinal-type gastric cancer. However, an accurate endoscopic diagnosis of IM is a clinical c...

    Authors: Xing-kang He, Dan Liu and Lei-min Sun
    Citation: BMC Gastroenterology 2016 16:109
  12. Previous studies have demonstrated that endoscopic ultrasound-fine needle aspiration (EUS-FNA) is a reliable tool for diagnosing pancreatic lesions; however, the reported sensitivity and specificity vary great...

    Authors: Omar Banafea, Fabian Pius Mghanga, Jinfang Zhao, Ruifeng Zhao and Liangru Zhu
    Citation: BMC Gastroenterology 2016 16:108
  13. Gastroparesis (Gp) is a poorly understood chronic gastrointestinal medical condition for which patient reported outcomes (PRO) are lacking. Previously developed symptoms scoring has been used for several decad...

    Authors: Teresa Cutts, Sandra Holmes, Archana Kedar, Karen Beatty, Mohammad K. Mohammad and Thomas Abell
    Citation: BMC Gastroenterology 2016 16:107
  14. Defects in distal oesophageal peristalsis was thought to be an indication of incomplete bolus transit (BT). However, the role of transition zone (TZ) defects in the BT in gastroesophageal reflux disease (GORD)...

    Authors: Yu-wen Li, Chen-xi Xie, Kai-Ming Wu, Min-hu Chen and Ying-lian Xiao
    Citation: BMC Gastroenterology 2016 16:106
  15. Plastic and covered metal stents need to be removed or exchanged within appropriate time in case of undesirable complications. However, it is not uncommon that patients do not follow the recommendation for fur...

    Authors: Yong Gu, Limei Wang, Lina Zhao, Zhiguo Liu, Hui Luo, Qin Tao, Rongchun Zhang, Shuixiang He, Xiangping Wang, Rui Huang, Linhui Zhang, Yanglin Pan and Xuegang Guo
    Citation: BMC Gastroenterology 2016 16:105
  16. Hepatitis B virus (HBV) genotype and its role in disease progression and patients’ response to antiviral treatment, is not well studied in Pakistan. This comprehensive study was aimed to determine the distribu...

    Authors: Majid Mahmood, Muhammad Asim Anwar, Azra Khanum, Nasib Zaman and Abida Raza
    Citation: BMC Gastroenterology 2016 16:104
  17. The ST2/IL-33 pathway has been related to ulcerative colitis (UC), and soluble ST2 (sST2), to disease severity. We tested the potential usefulness of sST2 as a predictive marker of treatment response and patie...

    Authors: David Díaz-Jiménez, Marjorie De la Fuente, Karen Dubois-Camacho, Glauben Landskron, Janitza Fuentes, Tamara Pérez, María Julieta González, Daniela Simian, Marcela A. Hermoso and Rodrigo Quera
    Citation: BMC Gastroenterology 2016 16:103
  18. Sometimes, no definite filling defect could be found by cholangiogram (ERC) during the endoscopic retrograde cholangio-pancreatiographic (ERCP) exam; even prior images had evidence of common bile duct stones (...

    Authors: Po-Hung Chiang, Kwok-Hung Lai, Tzung-Jiun Tsai, Kung-Hung Lin, Kai-Ming Wang, Sung-Shuo Kao, Wei-Chih Sun, Jin-Shiung Cheng, Ping-I Hsu, Wei-Lun Tsai, Wen-Chi Chen, Yun-Da Li, E-Ming Wang, Huey-Shyan Lin and Hoi-Hung Chan
    Citation: BMC Gastroenterology 2016 16:102
  19. Increasing morbidity and mortality from colorectal cancer is evident in recent years in the developing Asian nations. Particularly in Thailand and most neighbouring low-income countries, screening colonoscopy ...

    Authors: Bunchorn Siripongpreeda, Chulabhorn Mahidol, Navara Dusitanond, Tassanee Sriprayoon, Bunlung Muyphuag, Thaniya Sricharunrat, Narongchai Teerayatanakul, Watanya Chaiwong, Wipra Worasawate, Prassanee Sattayarungsee, Juthamas Sangthongdee, Jirapa Prarom, Gaidganok Sornsamdang, Kamonwan Soonklang, Kasiruck Wittayasak and Chirayu U. Auewarakul
    Citation: BMC Gastroenterology 2016 16:101
  20. Little is known of the prevalence of hepatitis B virus (HBV) infection and its effect on choice of therapy and disease course in patients with inflammatory bowel disease (IBD). We assessed the prevalence of HB...

    Authors: Heyson C. H. Chan, Vincent W. S. Wong, Grace L. H. Wong, Whitney Tang, Justin C. Y. Wu and Siew C. Ng
    Citation: BMC Gastroenterology 2016 16:100
  21. Recent data shows that patients with severe acute pancreatic might benefit from early intensive therapy, enteral nutrition and timely transfer to specialized centers. The early prophylactic use of antibiotics ...

    Authors: Andrius Karpavicius, Zilvinas Dambrauskas, Audrius Gradauskas, Arturas Samuilis, Kristina Zviniene, Juozas Kupcinskas, Gintautas Brimas, Artur Meckovski, Audrius Sileikis and Kestutis Strupas
    Citation: BMC Gastroenterology 2016 16:99
  22. Roux-en-Y reconstructive surgery excludes the biliopancreatic system from conventional endoscopic access. Balloon-assisted enteroscopy allows therapeutic endoscopic retrograde cholangiopancreatography (ERCP) i...

    Authors: Michael De Koning and Tom G. Moreels
    Citation: BMC Gastroenterology 2016 16:98
  23. This study analyzes the clinicopathologic and radiologic characteristics of malignant serous cystic neoplasm (SCN) of the pancreas through systematic review and an institutional case report.

    Authors: Jimi Huh, Jae Ho Byun, Seung-Mo Hong, Kyung Won Kim, Jin Hee Kim, Seung Soo Lee, Hyoung Jung Kim and Moon-Gyu Lee
    Citation: BMC Gastroenterology 2016 16:97
  24. In the medical literature are described only few clinical cases of esophageal food bolus impaction due to esophageal motility disorders. Moreover, the management of this condition is highly variable with no ev...

    Authors: Luigi Marano, Alessandro Cecchi, Federica Chiodo, Francesco Gullo, Pasquale Fiorillo, Luca Roncetti, Mattia Longaroni, Gianluca Proietti Silvestri, Silvano Lolli, Giorgio Nicolic and Alberto Patriti
    Citation: BMC Gastroenterology 2016 16:95
  25. Infection with Helicobacter pylori is associated with severe digestive diseases including chronic gastritis, peptic ulcer disease, and gastric cancer. Successful eradication of this common gastric pathogen in ind...

    Authors: Amin Talebi Bezmin Abadi and Johannes G. Kusters
    Citation: BMC Gastroenterology 2016 16:94
  26. Portal hypertensive gastropathy (PHG) is a frequently overlooked complication of liver cirrhosis (LC). The clinical implications of PHG as a prognostic factor of LC or a predictive factor for the development o...

    Authors: Chang Seok Bang, Hyo Sun Kim, Ki Tae Suk, Sung Eun Kim, Ji Won Park, Seung Ha Park, Hyoung Su Kim, Myoung Kuk Jang, Sang Hoon Park, Myung Seok Lee, Choong Kee Park and Dong Joon Kim
    Citation: BMC Gastroenterology 2016 16:93
  27. Fibrinogen storage disease (FSD) is a rare autosomal-dominant disorder caused by mutation in FGG, encoding the fibrinogen gamma chain. Here we report the first Han Chinese patient with FSD, caused by de novo fibr...

    Authors: Mei-Hong Zhang, A. S. Knisely, Neng-li Wang, Jing-Yu Gong and Jian-She Wang
    Citation: BMC Gastroenterology 2016 16:92
  28. Pegylated interferon alpha 2a, alpha 2b and ribavirin have been included to the National List of Essential Medicines (NLEM) for treatment of only chronic hepatitis C genotypes 2 and 3 in Thailand. This reimbur...

    Authors: Nattiya Kapol, Surasit Lochid-amnuay and Yot Teerawattananon
    Citation: BMC Gastroenterology 2016 16:91
  29. Colorectal cancer and its precursors are highly prevalent in developed countries. Estimates in the available literature for prevalence of right-sided-only lesions vary between 20.5 and 48.1 %, with association...

    Authors: Heather S. Laird-Fick, Gurveen Chahal, Ade Olomu, Joseph Gardiner, James Richard and Nikolay Dimitrov
    Citation: BMC Gastroenterology 2016 16:90
  30. Hepatic inflammatory pseudotumor (IPT) is a rare disease which often mimics a malignant tumor and is therefore often misdiagnosed and surgically resected. Recently, a concept of IgG4-related diseases (IgG4-RD)...

    Authors: Masayuki Shibata, Hiroyuki Matsubayashi, Tsuyoshi Aramaki, Katsuhiko Uesaka, Naoyuki Tsutsumi, Keiko Sasaki and Hiroyuki Ono
    Citation: BMC Gastroenterology 2016 16:89
  31. Laparoscopic Nissen fundoplication (LNF) is the most common surgical procedure for the surgical management of gastro-esophageal reflux disease (GERD). Laparoscopic Toupet fundoplication (LTF) has been reported...

    Authors: Xing Du, Zhiwei Hu, Chao Yan, Chao Zhang, Zhonggao Wang and Jimin Wu
    Citation: BMC Gastroenterology 2016 16:88
  32. Molecular studies suggest inhibition of colorectal mucosal polyamines (PAs) may be a promising approach to prevent colorectal cancer (CRC). Inhibition of ornithine decarboxylase (ODC) using low-dose eflornithi...

    Authors: Carol A. Burke, Evelien Dekker, N. Jewel Samadder, Elena Stoffel and Alfred Cohen
    Citation: BMC Gastroenterology 2016 16:87
  33. The human gut is the habitat for diverse and dynamic microbial ecosystem. The human microbiota plays a critical role in functions that sustain health and is a positive asset in host defenses. Establishment of ...

    Authors: Erigene Rutayisire, Kun Huang, Yehao Liu and Fangbiao Tao
    Citation: BMC Gastroenterology 2016 16:86
  34. Leukotriene B4 (LTB4R and LTB4R2) and cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2) contribute to malignant cell transformation. We aimed to investigate the expression of LTB4R, LTB4R2, CYSLTR1 and CYS...

    Authors: M. Venerito, C. Helmke, D. Jechorek, T. Wex, R. Rosania, K. Antweiler, J. Weigt and P. Malfertheiner
    Citation: BMC Gastroenterology 2016 16:85
  35. Butyrate is an energy source for colonocytes that is formed by bacterial fermentation of dietary fiber in the colon and that exerts broad anti-inflammatory activities. Although the administration of butyrate i...

    Authors: Mingming Zhang, Qian Zhou, Robert G. Dorfman, Xiaoli Huang, Tingting Fan, Hao Zhang, Jun Zhang and Chenggong Yu
    Citation: BMC Gastroenterology 2016 16:84
  36. Evidence supporting the associations between folate metabolizing gene polymorphisms and pancreatic cancer has been inconclusive. We examined their associations in a case-control study of Japanese subjects.

    Authors: Haruhisa Nakao, Kenji Wakai, Norimitsu Ishii, Yuji Kobayashi, Kiyoaki Ito, Masashi Yoneda, Mitsuru Mori, Masanori Nojima, Yasutoshi Kimura, Takao Endo, Masato Matsuyama, Hiroshi Ishii, Makoto Ueno, Sawako Kuruma, Naoto Egawa, Keitaro Matsuo…
    Citation: BMC Gastroenterology 2016 16:83
  37. There are few reports of the efficacy of adalimumab (ADA) for clinical remission and preventing postoperative recurrence in Crohn's disease (CD) in Asian real practice settings. We conducted a Japanese multice...

    Authors: Fuminao Takeshima, Daisuke Yoshikawa, Syuntaro Higashi, Tomohito Morisaki, Hidetoshi Oda, Maho Ikeda, Haruhisa Machida, Kayoko Matsushima, Hitomi Minami, Yuko Akazawa, Naoyuki Yamaguchi, Ken Ohnita, Hajime Isomoto, Masato Ueno and Kazuhiko Nakao
    Citation: BMC Gastroenterology 2016 16:82
  38. Poly(ADP-ribose) polymerase (PARP) participates in multi-organ failure in various inflammatory diseases including acute necrotizing pancreatitis (ANP). Since pancreatitis-associated adrenal insufficiency is pa...

    Authors: Jia Yu, Teng Zuo, Wenhong Deng, Qiao Shi, Peng Ma, Chen Chen, Liang Zhao, Kailiang Zhao and Weixing Wang
    Citation: BMC Gastroenterology 2016 16:81
  39. Approximately half of the world’s population is infected with Helicobacter pylori (H.pylori), a bacterium shown to be linked with a series of gastrointestinal diseases. A growing number of systematic reviews (...

    Authors: Yiqiao Xin, Jan Manson, Lindsay Govan, Robin Harbour, Jenny Bennison, Eleanor Watson and Olivia Wu
    Citation: BMC Gastroenterology 2016 16:80
  40. The <80 % Helicobacter pylori eradication rate with sequential therapy is unsatisfactory. Modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because H. pylori resista...

    Authors: Ju Yup Lee, Nayoung Kim, Kyung Sik Park, Hyun Jin Kim, Seon Mee Park, Gwang Ho Baik, Ki-Nam Shim, Jung Hwan Oh, Suck Chei Choi, Sung Eun Kim, Won Hee Kim, Seon-Young Park, Gwang Ha Kim, Bong Eun Lee, Yunju Jo and Su Jin Hong
    Citation: BMC Gastroenterology 2016 16:79
  41. Recent studies have implicated that members of the DICKKOPF (DKK) were causally involved in large number of human cancers. This study was designed to investigate the relationship between the genetic variations of...

    Authors: Juan Wu, Junfeng Zhang, Zhen Zhan, Qinhong Cao and Zhong Li
    Citation: BMC Gastroenterology 2016 16:78
  42. Epilepsy is associated with an increased mortality among cirrhosis patients, but the reasons are unknown. We aimed to determine whether epilepsy is a risk factor for developing hepatic encephalopathy (HE), whi...

    Authors: Peter Jepsen, Jakob Christensen, Karin Weissenborn, Hugh Watson and Hendrik Vilstrup
    Citation: BMC Gastroenterology 2016 16:77
  43. Association between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adu...

    Authors: Antti Kylökäs, Katri Kaukinen, Heini Huhtala, Pekka Collin, Markku Mäki and Kalle Kurppa
    Citation: BMC Gastroenterology 2016 16:76
  44. Toll-like receptors (TLRs) are effectors of the innate immune system that are able to recognize hepatitis C virus (HCV) and give rise to an immune response. Failure of interferon (IFN)-α-based treatment is rel...

    Authors: Chuan-Mo Lee, Tsung-Hui Hu, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen and Yi-Hao Yen
    Citation: BMC Gastroenterology 2016 16:73
  45. Identifying a precise demarcation line (DL) is indispensable for pathological complete en bloc endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). We evaluated the useful condition of chromo...

    Authors: Norifumi Numata, Shiro Oka, Shinji Tanaka, Yoshikazu Yoshifuku, Tomohiro Miwata, Yoji Sanomura, Koji Arihiro, Fumio Shimamoto and Kazuaki Chayama
    Citation: BMC Gastroenterology 2016 16:72
  46. Pruritus (itch) is a symptom commonly experienced by patients with cholestatic liver diseases such as primary biliary cholangitis (PBC, previously referred to as primary biliary cirrhosis). Bile acids (BAs) ha...

    Authors: Vinod S. Hegade, Stuart F. W. Kendrick, Robert L. Dobbins, Sam R. Miller, Duncan Richards, James Storey, George Dukes, Kim Gilchrist, Susan Vallow, Graeme J. Alexander, Margaret Corrigan, Gideon M. Hirschfield and David E. J. Jones
    Citation: BMC Gastroenterology 2016 16:71
  47. Difficult biliary cannulation in endoscopic retrograde cholangiopancreatography (ERCP) can result in failure of common bile duct (CBD) stone removal and pancreatitis. The present study aimed to report the effi...

    Authors: Chung-Mou Kuo, Yi-Chun Chiu, Chih-Ming Liang, Lung-Sheng Lu, Wei-Chen Tai, Yuan-Hung Kuo, Cheng-Kun Wu, Seng-Kee Chuah, Chi-Sin Changchien and Chung-Huang Kuo
    Citation: BMC Gastroenterology 2016 16:70

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