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Table 4 Risk genotypes related to BCH, ESCD and ESCC in the multinomial logistic regression models a

From: Multi-susceptibility genes associated with the risk of the development stages of esophageal squamous cell cancer in Feicheng County

Factors

BCH

OR(95%CI)

ESCD

OR(95%CI)

ESCC

OR(95%CI)

ORG(95%CI) #

MTHFR C677T

    

TT

0.91(0.59-1.40)

0.78(0.48-1.28)

1.85(1.02-3.34)

1.16(1.00-1.35)

CT

0.89(0.58-1.37)

0.56(0.34-1.03)

1.72(0.95-3.10)

 

TT&TC

0.90(0.62-1.32)

0.66(0.43-1.12)

1.71(1.01-2.91)

 

CC

1.00

1.00

1.00

 

MPO G463A

    

GG

1.09(0.64-1.86)

2.13(0.90-5.08)

0.96(0.52-1.78)

0.93(0.72-1.19)

GA&AA

1.00

1.00

1.00

 

CYP2E1 G1259C

    

C2/C2 & C1/C2

1.15(0.64-2.09)

0.79(0.38-1.62)

1,01(0.43-2.33)

0.94(0.77-1.14)

C1/C1

1.00

1.00

1.00

 

hOGG1 C326G

    

GG

1.56(0.71-3.43)

1.23(0.46-3.26)

0.50(0.14-1.81)

1.00(0.85-1.78)

GC

1.10(0.66-1.86)

2.33(1.24-4.36)

1.45(0.72-2.92)

 

GG&GC

1.2990.73-1.97)

2.08(1.14-3.76)

1.23(0.63-2.40)

 

CC

1.00

1.00

1.00

 

ALDH2

    

2*2

4.15(2.33-7.40)

4.54(2.32-8.89)

3.38(1.64-6.95)

1.52(1.30-1.77)

1*2

1.19(0.72-1.95)

0.65(0.34-1.22)

1.39(0.73-2.64)

 

2*2&1*2

1.73(1.07-2.81)

1.43(0.79-2.58)

1.80(0.97-3.38)

 

1*1

1.00

1.00

1.00

 
  1. a: Adjusted for age, sex, income, school year, smoking, drinking and family history of esophageal cancer. Abbreviations: BCH, Basal cell hyperplasia; ESCD, esophageal squamous cell dysplasia; ESCC, Esophageal Squamous cell cancer; ORG: generalized odds ratio.
  2. #: ORG: calculated by the software "ORGGASMA" of the web site htpp://biomath.med.uth.gr.(note:: added 0.5 to zero frequency of cell).