Keratin 8 variants are infrequent in patients with alcohol-related liver cirrhosis and do not associate with development of hepatocellular carcinoma

Table 2 Distribution of gene mutation in the ALC patients

Gene	Exon	Nucleotide Variants (DNA)	Amino Acid Variants	Patients	%
K8	E1	184 G→T	G62C	5	1,9
	E1	187 A→G	I63V	1*	0,38
	E6	1022 G→A	R341H	8	3,1
Total				14 (13)*	5,4 (5,0)

*Based on previous studies, K8 I63V represents a polymorphism rather than a biologically relevant K8 variant.

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