Association of an NFKB1 intron SNP (rs4648068) with gastric cancer patients in the Han Chinese population

BMC Gastroenterology

Table 4 Association between the genotype of the NFKB1 rs4648068 polymorphism and patient characteristics

	N	GG	AOR (95%CI)^Δ	Pvalue^Δ	GA	AOR (95%CI)^Δ	Pvalue^Δ	AA	AOR (95%CI)^Δ Pvalue^Δ	G	A	AOR (95%CI)*	Pvalue*
Clinical Stage
III + IV	128	33(25.8)	2.27(1.11 ~ 4.66)	0.025	62(48.4)	1.55(0.87 ~ 2.78)	0.139	33(25.8)	-	128(50.0)	128(50.0)	1.86(1.22 ~ 2.82)	0.004
I + II	120 20(16.7)	-			55(45.8)	-		45(37.5)	-	95(39.6)	145(60.4)	-
Tumor differentiation
Poor	118	29(24.6)	1.34(0.66-2.70)	0.418	52(44.1)	0.89(0.50 ~ 1.58)	0.680	37(31.4)	-	110(46.6)	126(53.4)	1.08(0.71 ~ 1.63)	0.729
Well & moderate	130	24(18.5)	-		65(50.0)	-		41(31.5)	-	113(43.5)	147(56.5)	-
Lymph node status
Positive	111	29(26.1)	2.90 (1.40 ~ 6.03)	0.004	59(53.2)	2.44(1.33-4.50)	0.004	23(20.7)	-	117(52.7)	105(47.3)	2.67(1.72 ~ 4.13)	0.001
Negative	137	24(17.5)	-		58(42.3)	-		55(40.1)		106(38.7)	168(61.3)	-
Serosa invasion
Positive	126	34(27.0)	2.78(1.34 ~ 5.75)	0.006	62(49.2)	1.74(0.97-3.13)	0.064	30(23.8)	-	130(51.6)	122 (48.4)	2.17(1.42 ~ 3.31)	0.001
Negative	122	19(15.6)	-		55(45.1)			48(39.3)	-	93(38.1)	151 (61.9)	-

^Δ, Multivariate logistic regression adjusted by age and gender (genotype AA, AOR = 1.00); *, multivariate logistic regression adjusted by age and gender (A carrier, AOR = 1.00).

ISSN: 1471-230X