Table 7 Possible causes of impairment of the intestinal barrier
From: Intestinal permeability – a new target for disease prevention and therapy
Nutritional factors | Tight junction downregulation |
Histone deacetylase (HDAC) inhibitors | |
ENS modulators | |
Infections & toxins | Viral intestinal infections |
Environmental toxins | |
Toxic food | |
“Hygiene hypothesis” | Sterile environment |
Lack of farming | |
“Lifestyle hypothesis” | Impaired function and diversity |
of the intestinal microbiota | |
Endogenous factors | Hypoperfusion of the intestine |
Chronic inflammation/autoimmunity |